How healthcare accelerator programs are changing care

As healthcare faces mounting pressures, from rising costs and an aging population to widening disparities, forward thinking innovations are more essential than ever.

Accelerator programs have proven to be powerful launchpads for health tech companies, often combining resources, mentorship, and technology that startups otherwise would not have access to. By joining these fast-moving platforms, startups are better able to rapidly innovate, enhance, and scale their healthcare solutions, bringing transformative approaches to hospitals and patients faster.

So, why are healthcare accelerators becoming essential to the evolution of the industry? There are key reasons why these programs are reshaping health innovation and explanations how they are helping to make care more personalized, proactive, and accessible.

Empowering growth and scaling impact       

Healthcare accelerator programs offer a powerful combination of guidance, resources, and connections to help early-stage startups grow, scale, and succeed in a complex industry. 

Participants typically benefit from: 

  • Expert mentorship from seasoned healthcare professionals, entrepreneurs, and industry leaders to navigate clinical, regulatory, and business challenges
  • Access to valuable resources such as clinical data, testing environments, and technical infrastructure to refine and validate health tech solutions
  • Strategic support for growth including investor introductions, partnership opportunities, and go-to-market guidance to expand reach and impact 

Speeding up innovation 

Accelerators help startups and early-stage companies bring their solutions to market faster by streamlining the path through one of the most complex industries: healthcare. Traditionally, innovation in this space is slowed by regulatory hurdles, extended sales cycles, clinical validation requirements, and fragmented data systems.  

Through structured support, accelerators help companies refine their product market fit, navigate compliance and regulatory landscapes, integrate with healthcare systems, and gather the clinical evidence needed to build trust and credibility. They also open doors to early pilot opportunities, customer feedback, and strategic partnerships, compressing what could take years into just a few months. 

By removing barriers and accelerating critical early steps, these programs enable digital health innovators to reach the market more efficiently, with stronger solutions and a clearer path to impact. 

Connecting startups with key stakeholders 

Today, many accelerator programs are developed by large healthcare organizations that are driving change from within. These accelerator programs are especially beneficial to startups since they have strong partnerships with hospitals, pharma companies, insurance providers, and regulators. This gives startups a chance to validate their ideas in real-world settings, gather clinical feedback early, and scale more effectively.  

Many accelerators also bring together people from different fields; doctors, engineers, data scientists, and designers, encouraging fresh perspectives on persistent problems like chronic disease management, preventative care, data interoperability, and patient engagement. 

Breaking barriers to global expansion 

Healthcare accelerator programs act as gateways for international digital health companies looking to enter the U.S. market, often considered one of the most complex and highly regulated healthcare landscapes in the world. These programs provide tailored support to navigate U.S. compliance standards, understand payer and provider dynamics, and tailor offerings to meet the needs of U.S. patients and care delivery models. 

Through market-specific mentorship, strategic introductions, and access to a robust health innovation ecosystem, accelerators help international startups overcome geographic and regulatory barriers, enabling global ideas to scale and make an impact where they’re needed most. 

Building the future of healthcare

The role of healthcare accelerator programs extends far beyond startup support. They are helping to redefine how innovation happens, shifting it from isolated efforts to collaborative ecosystems of change. By bridging gaps between early-stage technology and real-world implementation, these programs play a critical role in making healthcare more personalized, preventative, and equitable.

As the digital transformation of healthcare continues, accelerator programs will remain indispensable in cultivating the next generation of breakthroughs, ensuring that bold ideas are not only born, but brought to life in meaningful, measurable ways.

Spotlight: Mayo Clinic Platform_Accelerate

One standout example of this innovation-forward approach is Mayo Clinic Platform_Accelerate, a 30-week accelerator program designed to help health tech startups reach market readiness. Participants gain access to de-identified clinical data, prototyping labs, and guidance from experts across clinical, regulatory, and business domains.

By combining Mayo Clinic’s legacy of clinical excellence with a forward-thinking innovation model, the Mayo Clinic Platform_Accelerate program helps promising startups to refine their solutions and prepare for meaningful scale, transforming how care is delivered across the continuum.

Finding value in accelerator programs

In a time when healthcare must evolve faster than ever, accelerator programs have become vital to the industry’s future. By supporting early-stage innovators with the tools, mentorship, and networks they need to succeed, these programs are paving the way for smarter, safer, and more connected care.

Whether tackling chronic disease, reimagining patient engagement, or unlocking the power of data, the startups nurtured in accelerator programs are helping to shape a more resilient and responsive health system, one innovation at a time.

This content was produced by Mayo Clinic Platform. It was not written by MIT Technology Review’s editorial staff.

Fighting forever chemicals and startup fatigue

What if we could permanently remove the toxic “forever chemicals” contaminating our water? That’s the driving force behind Michigan-based startup Enspired Solutions, founded by environmental toxicologist Denise Kay and chemical engineer Meng Wang. The duo left corporate consulting in the rearview mirror to take on one of the most pervasive environmental challenges: PFAS.

“PFAS is referred to as a forever chemical because it is so resistant to break down,” says Kay. “It does not break down naturally in the environment, so it just circles around and around. This chemistry, which would break that cycle and break the molecule apart, could really support the health of all of us.”

Basing the company in Michigan was both a strategic and a practical strategy. The state has been a leader in PFAS regulation with a startup infrastructure—buoyed by the Michigan Economic Development Corporation (MEDC)—that helped turn an ambitious vision into a viable business.

From intellectual property analyses to forecasting finances and fundraising guidance, the MEDC’s programs offered Kay and Wang the resources to focus on building their PFASigator: a machine the size of two large refrigerators that uses ultraviolet light and chemistry to break down PFAS in water. In other words, “it essentially eats PFAS.”

Despite the support from the MEDC, the journey has been far from smooth. “As people say, being an entrepreneur and running a startup is like a rollercoaster,” Kay says. “You have high moments, and you have very low moments when you think nothing’s ever going to move forward.”

Without revenue or salaries in the early days, the co-founders had to be sustained by something greater than financial incentive.

“If problem solving and learning new talents do not provide sufficient intrinsic reward for a founder to be satisfied throughout what I guarantee will be a long duration effort, then that founder may need to reset their expectations. Because the financial rewards of entrepreneurship are small throughout the process.”

Still, Kay remains optimistic about the road ahead for Enspired Solutions, for clean water innovation, and for other founders walking down a similar path. “Often, founders are coached about formulas for fundraising, formulas for startup success. Learning those formulas and expectations is important, but it’s also important to not forget that it’s your creativity and innovation and foresight that got you to the place you’re in and drove you to start a company. Ultimately, people still want to see that shine through.”

This episode of Business Lab is produced in partnership with the Michigan Economic Development Corporation.

Full Transcript

Megan Tatum: From MIT Technology Review, I’m Megan Tatum. This is Business Lab, the show that helps business leaders make sense of new technologies coming out of the lab and into the marketplace.

Today’s episode is brought to you in partnership with the Michigan Economic Development Corporation.

Our topic today is launching a technology startup in the US state of Michigan. Building out an innovative idea into a viable product and company requires knowledge and resources that individuals might not have. That’s why the Michigan Economic Development Corporation, or the MEDC, has launched an innovation campaign to support technology entrepreneurs.

Two words for you: startup ecosystem.

My guest is Dr. Denise Kay, the co-founder and CEO at Enspired Solutions, a Michigan-based startup focused on removing synthetic forever chemicals called PFAS from water.

Welcome, Denise.

Dr. Denise Kay: Hi, Megan.

Megan: Hi. Thank you so much for joining us. To get us started, Denise, I wondered if we could talk about Enspired Solutions a bit more. How did the idea come about, and what does your company do?

Denise: Well, my co-founder, Meng, and I had careers in consulting, advising clients on the fate and toxicity of chemicals in the environment. What we did was evaluate how chemicals moved through soil, water, and air, and what toxic impact they might have on humans and wildlife. That put us in a really unique position to see early on the environmental and health ramifications of the manmade chemical PFAS in our environment.

When we learned of a very novel and elegant chemistry that could effectively destroy PFAS, we could foresee the value in making this chemistry available for commercial use and the potential for a significant positive impact on maintaining healthy water resources for all of us.

Like you mentioned, PFAS is referred to as a forever chemical because it is so resistant to break down. It does not break down naturally in the environment, so it just circles around and around. This chemistry, which would break that cycle and break the molecule apart, could really support the health of all of us.

Ultimately, Meng and I quit our jobs, and we founded Enspired Solutions. Our objective was to design, manufacture, and sell commercial-scale equipment that destroys PFAS in water based on this laboratory bench-scale chemistry that had been discovered, the goal being that this toxic contaminant does not continue to circulate in our natural resources.

At this point, we have won an award from the EPA and Department of Defense, and proven our technology in over 200 different water samples ranging from groundwater, surface water, landfill leachate, industrial wastewater, [and] municipal wastewater. It’s really everywhere. What we’re seeing traction in right now is customer applications managing semiconductor waste. Groundwater and surface water around airports tend to be high in PFAS. Centralized waste disposal facilities that collect and manage PFAS-contaminated liquids. And also, even transitioning firetrucks to PFAS-free firefighting foams.

Megan: Fantastic. That’s a huge breadth of applications, incredible stuff.

Denise: Yeah.

Megan: You launched about four years ago now. I wondered what factors made Michigan the right place to build and grow the company?

Denise: That is something we put a lot of thought into, because I live in Michigan, and Meng lives in Illinois, so when it was just the two of us, there was even that, “Okay, what is going to be our headquarters?” We looked at a number of factors.

Some of the things we considered were rentable incubator space. By incubator, I mean startup incubators or innovation centers. The startup support network, a pool of future employees, and what position the state agencies were taking regarding PFAS.

While thinking about all those things and investigating our communities, in Michigan, we found a space to rent where we could do chemistry experiments in an incubator environment. Somewhere where we were surrounded by other entrepreneurs, which we knew was something we had to learn how to do. We were great chemists, but we knew that surrounding ourselves with those skills that could be a gap for us was going to be helpful.

Also, we know that Michigan has moved much faster than other states in identifying PFAS sources in the environment and regulating its presence. This combination was something we knew would be the right place for starting our business and having success.

Megan: It was a perfect setting for those two reasons. What were the first stages of your journey working with the Michigan Economic Development Corporation, the MEDC?

Denise: Well, both my co-founder, Meng, and I are first-time entrepreneurs. MEDC was one of the first resources I reached out to, starting from a Google search. They were an information resource we turned to initially, and then again and again for learning some fundamental skills. And receiving one-on-one expert mentorship for things like business contracts, understanding intellectual property landscapes, tracking and forecasting our business finances, and even how to approach fundraising.

Megan: Wow. It sounds like they were an invaluable resource in those early days. How did early-stage research and development progress from that point? What were the key MEDC services and programs you used to get started?

Denise: Well, our business is based on cutting-edge science, truly cutting-edge science. Understanding the intellectual property landscape, which is a term used to describe intellectual property, patents, trademarks, trade secrets that are related to the science we were founding our business on, it was very important. So that we knew we were starting on a path, that we wouldn’t hit a wall three years from now.

The MEDC performed an IP landscape survey for us. They searched the breadth of patents, and patent applications, and trademarks, and those things, and provided that for Meng and me to review and consider our position before really, really digging in and spending a lot of emotional time and money on the business.

The MEDC also helped us early on create a model in Excel for tracking business financing and forecasting, forecasting our future financial needs, so that we could be proactive instead of reactive to financial limitations. We knew it wasn’t going to be inexpensive to design and build a piece of equipment that’s the size of two very large refrigerators that had never been built before. That type of financial-forward modeling helped us figure out when we would need to start fundraising and taking in investments. As we progressed along that, the MEDC also provided support of an attorney who reviewed contract language to make sure that we really understood various agreements that we were signing.

Megan: Right. You mentioned that you and your co-founder were first-time entrepreneurs, as you put it. Tech acumen and business acumen are very different sets of skills. I wondered, what was the process like, developing this innovative technology while also building out a viable business plan?

Denise: Well, Meng is a brilliant individual. She is a chemical engineer who also has an MBA. Meng had fantastic training to help understand the basis of how businesses function, in addition to understanding both the engineering and the chemistry behind what we were trying to do.

I am an environmental toxicologist by training. I’ve had a longer career than Meng in that field. Over time, I have grown new offices and established new offices for different consulting firms I’ve worked for. I had the experience with people, space, culture, and running a business from that side. Meng has the financial MBA knowledge basis for a business. We’re both excellent chemists and engineers, and those types of things.

We had much of the necessary knowledge, at least to take the first steps forward. The challenge became the hard limit of 24 hours in a day and no revenue to hire any support. That’s when the startup support networks like the MEDC became invaluable.

It was simply impossible to do everything that needed to be done, especially while we were learning what we were doing. The MEDC and other programs provided support to take some of that load off us, but also helped us to learn to implement the new skills in an efficient manner, less stumbling.

Megan: So many things to juggle, isn’t there, in starting a company. I wondered, in that vein, could you share some successes and highlights from your journey so far? Any partnerships or projects that you’re excited about that you could share with us?

Denise: As people say, being an entrepreneur and running a startup is like a rollercoaster. You have high moments and you have very low moments when you think nothing’s ever going to move forward. I’d love to talk about some of the highlights. Our machine, which we call the PFASigator.

First of all, coming up with that name has a fun story behind it. The machine is, like I said, about the size of two large refrigerators. It’s very large, and it breaks down PFAS in water. The machine takes in water that has PFAS in it, we add a couple of liquid chemicals, then a very intense ultraviolet light shines on that water, which catalyzes a chemical reaction called reductive defluorination. When all of this is happening and the PFAS molecules are being broken apart to nontoxic compounds, to an outsider, it all still just looks like water with a light shining on it. But the machine is big, and it essentially eats PFAS.

Meng and I were bantering, and her young, six-year-old son was in the background at the time. We were throwing names around. Thomas called out, “The PFASigator!” We were like, “Ooh, there’s something there.”

Megan: It’s a great name.

Denise: It matches what we do, and it’s a memorable name. We’ve really had fun with that throughout. That was an early highlight, and we’ve stuck with that name.

The next highlight I’d say was standing next to our first fully functioning PFASigator. It was big. It was all stainless steel. Meng and I had never been part of building a physical, large object like that. Just standing there, and the picture we have of us, it was exhilarating. That was a magnificent feeling.

Selling our first machine was a day that everyone in the company, I think we were about eight at that point, received a bottle of champagne.

Megan: Fantastic.

Denise: For a startup to go from zero to one, they call it, you’ve sold nothing to you’ve sold something. That’s a real strong milestone and was a celebration for us.

I’d say most recently, Enspired has been awarded a very exciting project in Michigan. It is in the contracting phase, so I can’t reveal too many details. But it is with a progressive municipality that will have our PFASigator permanently installed, destroying PFAS. That kind of movement from zero to one, and then a significant contract that will raise the visibility of the effectiveness of our approach and machine, has really buoyed our energy and is pushing us forward. It’s amazing to know we are now having an impact on the sustainability of water resources. That’s what we started the company for.

Megan: Awesome. You have some incredible milestones there. But it’s a hard journey, as you’ve said as well, being an entrepreneur. I wondered, finally, what advice would you offer to burgeoning entrepreneurs given your own experience?

Denise: I would advise that if problem solving and learning new talents do not provide sufficient intrinsic reward for a founder to be satisfied throughout what I guarantee will be a long duration effort, then that founder may need to reset their expectations, because the financial rewards of entrepreneurship are small throughout the process.

Meng and I put [in] some of our personal funds and took no salary, and worked harder than we ever had in our lives for at least a year and a half before we were able to take a small salary. The financial rewards are small throughout the process of being a startup. The rewards are delayed, and in many cases, for many startups, the financial rewards never materialize.

It’s a tough journey, and you have to love being on that journey, and be intrinsically rewarded for that for the sake of the journey itself, or you’ll be a very unhappy founder.

Megan: It needs to be something you’re as passionate about as I can tell you are about the work you’re doing at Enspired Solutions.

Denise: There’s probably one other thing I’d like to add to that.

Megan: Of course.

Denise: Often, founders are coached about formulas for fundraising, formulas for startup success. Learning those formulas and expectations is important, but it’s also important to not forget that it’s your creativity and innovation and foresight that got you to the place you’re in and drove you to start a company. Ultimately, people still want to see that shine through.”

Megan: That’s fantastic advice. Thank you so much, Denise.

That was Dr. Denise Kay, the co-founder and CEO at Enspired Solutions, whom I spoke with from an unexpectedly sunny Brighton, England.

That’s it for this episode of Business Lab. I’m your host, Megan Tatum. I’m a contributing editor and host for Insights, the custom publishing division of MIT Technology Review. We were founded in 1899 at the Massachusetts Institute of Technology. You can find us in print, on the web, and at events each year around the world. For more information about us and the show, please check out our website at technologyreview.com.

This show is available wherever you get your podcasts. If you enjoyed this episode, we hope you’ll take a moment to rate and review us. Business Lab is a production of MIT Technology Review, and this episode was produced by Giro Studios. Thanks for listening.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

This content was researched, designed, and written entirely by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

Finding value from AI agents from day one

Imagine AI so sophisticated it could read a customer’s mind? Or identify and close a cybersecurity loophole weeks before hackers strike? How about a team of AI agents equipped to restructure a global supply chain and circumnavigate looming geopolitical disruption? Such disruptive possibilities explain why agentic AI is sending ripples of excitement through corporate boardrooms. 

Although still so early in its development that there lacks consensus on a single, shared definition, agentic AI refers loosely to a suite of AI systems capable of connected and autonomous decision-making with zero or limited human intervention. In scenarios where traditional AI typically requires explicit prompts or instructions for each step, agentic AI will independently execute tasks, learning and adapting to its environment to refine decisions over time. 

From assuming oversight for complex workflows, such as procurement or recruitment, to carrying out proactive cybersecurity checks or automating support, enterprises are abuzz at the potential use cases for agentic AI. 

According to one Capgemini survey, 50% of business executives are set to invest in and implement AI agents in their organizations in 2025, up from just 10% currently. Gartner has also forecast that 33% of enterprise software applications will incorporate agentic AI by 2028. For context, in 2024 that proportion was less than 1%. 

“It’s creating such a buzz – software enthusiasts seeing the possibilities unlocked by LLMs, venture capitalists wanting to find the next big thing, companies trying to find the ‘killer app,” says Matt McLarty, chief technology officer at Boomi. But, he adds, “right now organizations are struggling to get out of the starting blocks.” 

The challenge is that many organizations are so caught up in the excitement that they risk attempting to run before they can walk when it comes to deployment of agentic AI, believes McLarty. And in so doing they risk turning it from potential business breakthrough into a source of cost, complexity, and confusion.

Keeping agentic AI simple 

The heady capabilities of agentic AI have created understandable temptation for senior business leaders to rush in, acting on impulse rather than insight risks turning the technology into a solution in search of a problem, points out McLarty. 

It’s a scenario that’s unfolded with previous technologies. The decoupling of Blockchain from Bitcoin in 2014 paved the way for a Blockchain 2.0 boom in which organizations rushed to explore the applications for a digital, decentralized ledger beyond currency. But a decade on, the technology has fallen far short of forecasts at the time, dogged by technology limitations and obfuscated use cases. 

“I do see Blockchain as a cautionary tale,” says McLarty. “The hype and ultimate lack of adoption is definitely a path the agentic AI movement should avoid.” He explains, “The problem with Blockchain is that people struggle to find use cases where it applies as a solution, and even when they find the use cases, there is often a simpler and cheaper solution,” he adds. “I think agentic AI can do things no other solution can, in terms of contextual reasoning and dynamic execution. But as technologists, we get so excited about the technology, sometimes we lose sight of the business problem.”

Instead of diving in headfirst, McLarty advocates for an iterative attitude toward applications of agentic AI, targeting “low-hanging fruit” and incremental use cases. This includes focusing investment on the worker agents that are set to make up the components of more sophisticated, multi-agent agentic systems further down the road. 

However, with a narrower, more prescribed remit, these AI agents with agentic capabilities can add instant value. Enabled with natural language processing (NLP) they can be used to bridge the linguistic shortfalls in current chat agents for example or adaptively carry out rote tasks via dynamic automation. 

“Current rote automation processes generate a lot of value for organizations today, but they can lead to a lot of manual exception processing,” points out McLarty. “Agentic exception handling agents can eliminate a lot of that.” 

It’s also essential to avoid use cases for agentic AI that could be addressed with a cheaper and simpler technology. “Configuring a self-manager, ephemeral agent swarm may sound exciting and be exhilarating to build, but maybe you can just solve the problem with a simple reasoning agent that has access to some in-house contextual data and API-based tools,” says McLarty. “Let’s call it the KASS principle: Keep agents simple, stupid.”

Connecting the dots

The future value of agentic AI will lie in its interoperability and organizations that prioritize this pillar at the earliest phase of their adoption will find themselves ahead of the curve. 

As McLarty explains, the usefulness of agentic AI agents in scenarios like customer support chats lies in their combination of four elements: a defined business scope, large language models (LLM), the wider context derived from an organization’s existing data, and capabilities executed through its core applications. These latter two rely on in-built interoperability. For example, an AI agent tasked with onboarding new employees will require access to updated HR policies, asset catalogs and IT. “Organizations can get a massive head start on business value through AI agents by having interoperable data and applications to plug and play with agents,” he says. 

Agent-to-agent frameworks like the model context protocol (MCP) – an open and standardized plug-and-play that connects AI models to internal (or external) information sources – can be layered onto an existing API architecture to embed connectedness from the outset. And while it might feel like an additional hurdle now, in the longer-term those organizations that make this investment early will reap the benefits. 

“The icing on the cake for interoperability is that all the work you do to connect agents to data and applications now will help you prepare for the multi-agent future where interoperability between agents will be essential,” says McLarty. 

In this future, multi-agent systems will work collectively on more intricate, cross-functional tasks. Agentic systems will draw on AI agents across inventory, logistics and production to coordinate and optimize supply chain management for example or perform complex assembly tasks. 

Conscious that this is where the technology is headed, third-party developers are already beginning to offer multi-agent capability. In December, Amazon launched such a tool for its Bedrock service, providing users access to specialized agents coordinated by a supervisor agent capable of breaking down requests, delegating tasks and consolidating outputs. 

But though such an off-the-rack solution has the advantage of allowing enterprises to bypass both the risk and complexity in leveraging such capabilities, the digital heterogeneity of larger organizations in particular will likely mean – in the longer-term at least – they’ll need to rely on their own API architecture to realize the full potential in multi-agent systems.

McLarty’s advice is simple, “This is definitely a time to ground yourself in the business problem, and only go as far as you need to with the solution.”

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

This content was researched, designed, and written entirely by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

Building community and clean air solutions

When Darren Riley moved to Detroit seven years ago, he didn’t expect the city’s air to change his life—literally. Developing asthma as an adult opened his eyes to a much larger problem: the invisible but pervasive impact of air pollution on the health of marginalized communities.

“I was fascinated about why we don’t have the data we need,” Riley recalls, “or why we don’t have the infrastructure to solve these issues, to understand where pollution is coming from, how it’s impacting our communities, so that we can solve these problems and make an equitable breathing environment for everybody.”

That personal reckoning sparked the idea for JustAir, a Michigan-based clean-tech startup building neighborhood-level air quality monitoring tools. The goal is simple but urgent: provide communities with access to hyper-local data so they can better manage pollution and protect public health. As Riley puts it, “JustAir is solving the problem of how to better manage local pollution so that we can make sure our communities, our lifestyles—where we work, where we play, and where we learn—are really protected.”

Founded during the height of the pandemic, when the connection between health disparities and air quality became impossible to ignore, JustAir now partners with local governments, health departments, and community residents to deploy monitoring networks that offer key data relevant to everything from policy to personal decision-making.

From the start, the Michigan Economic Development Corporation (MEDC) offered key support that helped turn JustAir’s bold vision into technical infrastructure. Through the MEDC’s early-stage funding partners and a network of mentorship and resources known as SmartZones, JustAir sharpened its product-market fit and gained critical momentum.

Success for Riley isn’t just about scale, it’s about impact. “It warms my heart, and it shows that we’re doing exactly what we said we wanted to do,” Riley says, “which is to make sure that communities have the data that they deserve to create the future, the clean, healthy future that they desperately need.”

To other burgeoning entrepreneurs, Riley sees a sense of community as key to lasting and impactful change. “When people are celebrating you with your head up, and then when people are helping you put your chin up when your head’s down, I think it’s so, so critical. I found that here in Michigan, and also found it here in our community, right here in Detroit. Passion and finding a community that’s going to help get you through the journey is all it takes.”

This episode of Business Lab is produced in association with the Michigan Economic Development Corporation.

Full Transcript

Megan Tatum: From MIT Technology Review, I’m Megan Tatum, and this is Business Lab, the show that helps business leaders make sense of new technologies coming out of the lab and into the marketplace.

Today’s episode is brought to you in partnership with the Michigan Economic Development Corporation.

Our topic today is building a technology startup in the U.S. state of Michigan. Taking an innovative idea to a full-fledged product and company requires resources that individuals might not have. That’s why the Michigan Economic Development Corporation, the MEDC, has launched an innovation campaign to support technology entrepreneurs.

Two words for you: startup ecosystem.

My guest is Darren Riley, the co-founder and CEO at JustAir, a clean air startup that began its journey in Michigan.

Welcome, Darren.

Darren Riley: Hi. Thanks for having me.

Megan: Thank you ever so much for being with us. To get us started, let’s just talk a bit about JustAir. How did the idea for the company come about, and what does your company do as well?

Darren: Yeah, absolutely. The real thesis of JustAir, is really a combination of one, my personal experience but also my professional experience. On the professional side, background in software engineering, graduated from Carnegie Mellon University, but I was always fascinated by how to use technology to really support and innovate and really push the frontier on issues that are near and dear to my heart. Coming from Houston, Texas, coming from communities that often are restricted with certain issues, systemic issues, is something that I always carried in my heart.

And on the personal side, it was around seven years ago when I moved to Detroit, in Southwest Detroit, where I developed asthma. Not growing up with asthma and not developing any issues, having that disease of the lungs really opened my eyes to just how much our environment impacts our health and well-being.

The combination of those, that pain point and also my background in technology, I was fascinated about why we don’t have the data we need or why we don’t have the infrastructure to solve these issues, to understand where pollution is coming from, how it’s impacting our communities, so that we can solve these problems and make an equitable breathing environment for everybody. That’s kind of what birthed JustAir in a way.

And actually, it was around COVID-19 where we really started to push forward, where we saw all this information and research around health disparities and a lot of the issues of mortality rates around COVID-19, which kind of coincides with COPD, asthma, and other diseases that are often overburdened in communities that look like ours, in Black and brown communities. That’s kind of where we got our start.

And what is JustAir today? JustAir is solving the problem of how to better manage local pollution so that we can make sure our communities, our lifestyles—where we work, where we play, and where we learn—are really protected. And, so, what JustAir does is build hyper-local neighborhood-level air quality monitoring networks. Communities have access to the data, policymakers and decision-makers can use that data to really influence and push things to help protect the community, but also other stakeholders can use the data to move the environment to a healthier state. So that’s where we are, and we’re four years strong, and I’m really excited to be a part of this journey here in Michigan.

Megan: So you launched about four years ago now. Why did you choose to build and grow just there in Michigan?

Darren: Yeah, I think a combination of things, the reason why I chose to start here and be intentional about building our team here. I think first is really around the ecosystem support around Michigan. So the MEDC has a network of what we call SmartZones that really offer funding, resources, mentorship, advisory on the different challenges that can range from capital, legal, and other issues that kind of hold an entrepreneur from just getting out there and putting their product in the market. First and foremost, I’m super thankful and grateful for just the state really focusing on and putting entrepreneurs first in that regard.

I think secondly is community. I really felt a strong sense of community here in Detroit. One of the founding members of an organization called Black Tech Saturdays, which sees over hundreds, 500-1,000 folks almost every Saturday of the month, just really sharing and really engaging with tech-curious folks from all different walks of life, but making intentional space for folks who are often left out of those rooms and out of those conversations. And just really seeing a peer network of entrepreneurs who come from a similar cultural background or a similar situation, really going after it together and helping each other navigate some issues.

And then lastly, I talk about this a lot, but problem-solution fit. Being here in Detroit where I developed asthma, where we have many issues and many around the environment that have hit some communities the hardest, right here in Detroit in my own backyard I really want to be very narrowly focused and make sure that I’m building something that actually solves the problem that got me on this journey in the first place. Not thinking about regional-wide, different country, international, et cetera, but how do we build something right here in the backyard that solves the problem for my neighbors and makes sure that we can make a real difference in the community. So, from the community to the problem that I really care about and make sure we solve, and then also just the ecosystem support is why we’re here in Michigan and why we plan to really grow and really be a part of this movement.

Megan: Fantastic. And you’ve touched on a few of those already, but as you were getting started, what specific resources, partnerships, or community support helped you navigate the early-stage research and development stages?

Darren: One example, really early, actually, I forgot about this for a while, but we have a Business Accelerator Fund here in Michigan where there’s funding offered to entrepreneurs for technical assistance. I used that to operationalize some of our technical roadmap processes to build out the infrastructure that we really intended to do. So, that real funding that was non-dilutive that the state provided helped accelerate some of those issues in the early days, where it was just myself and advisors going after this problem. And so now, where we are today, there are funds that receive funding from MEDC, so local funds and venture capital that help you get your first check. Those are really helpful as well. All that to say is basically a combination of funding primary source, but also strategically, that funding is going towards product positioning and product-market fit. Those were some of the two core examples that have been beneficial.

And then, I think the last thing I’ll mention as well, MEDC and a lot of the SmartZones within the state, these SmartZones are just bucketed in different regions and areas, so you have Ann Arbor, you’ve got Detroit, you have Grand Rapids, the whole nine yards, having these events and creating these clusters, if you will, of density of entrepreneurs, I think is super, super critical. I’ve experienced in New York, Chicago, and San Francisco, and other bigger ecosystems that density is so critical to where you’re constantly rubbing shoulders with the next entrepreneur, the next investor, the next customer, to really kind of accelerate that velocity of your journey.

Megan: Yeah. Having that ecosystem makes such a difference, doesn’t it?

Darren: Oh yeah, absolutely.

Megan: And tech acumen and business acumen are very different sets of skills. I wonder what was the process like developing out your technology whilst also building out a viable business plan?

Darren: I think I have a real unique opportunity. Having a software background, I code all the time, felt I had a lot of ideas, always joked that I had a Google Drive of 30 ideas that never worked, that I never showed anybody. I really felt I had that piece. What I was missing in my journey and why nothing ever came to fruition was just the simple principles of, are you solving a real problem, a real pain point for a customer?

Two things on the business acumen side are having an affinity for the problem. I truly believe that going on the entrepreneurial journey is lonely, it’s risky, it’s stressful, and tiring. The more I can wake up in the morning and think about [how] the problems that we solve could actually result in a breath of clean air for someone who may not have that awareness or have the tools to advocate on their behalf, just having that extra motivation and having that affinity towards a problem that I feel really deeply, I think does help.

But I think also from the business acumen side of things, I had the opportunity to work at an organization called Endeavor based here in Michigan, where I was on the other side of an entrepreneur resource support organization. I got to see founders from high-growth companies throughout Michigan, series A, series B, retail, fintech, the whole nine yards, health tech, and seeing where are the challenges, where are things going well and where things are going wrong, from co-founder struggles to missing the market timing or going through banking issues from a couple years ago and all that stuff. All those things really help build a muscle memory of, I don’t have all the answers, but being able to pull through those experiences and pattern matching does help as well, from how you actually build a business from zero, from product-market fit to scale and grow.

Megan: Yeah, absolutely. And as you say, it can be a stressful journey, life as an entrepreneur, but I wonder if you could also share some highlights from your journey so far, any partnerships or projects that you’re really excited about at the moment?

Darren: I think the first and foremost highlight [that] I didn’t realize I would come to enjoy so much is certainly my team. Being able to work with people who are aligned in passionate values and just kind of the culture and the focus is immensely valuable. If I’m going to spend this many hours in a week or in a year, I’d love to spend it with folks who are really passionate about it. I want to see them succeed. So I think first and foremost, I think the biggest success is really just the fortunate opportunity to work with people I really enjoy working with.

The others I’ll mention [are] we have one of the largest county-owned monitoring networks in the country within Wayne County. The Health Department of Wayne County and Executive Warren Evans established this partnership where we deployed 100 fixed monitors throughout Wayne County to understand the patterns of local pollution to where we can help combat some of these issues where we are ranked F in air quality from the Lung Association, or Detroit is the third-worst from Asthma and Allergy Foundation of America, the third-worst place to live in with asthma. So, how do we really look at this data and tell the story, and how can we really mitigate solutions, while also giving data to the public so that they can navigate the world that’s happening to them. That’s one of our critical partnerships.

We’re also very excited, we just got announced in Fast Company as one of the most innovative companies of 2025, so woo-hoo to that.

Megan: Congratulations.

Darren: It is really exciting, yeah, in the social impact, social good category. There are many, many more, but I think the last one, I’m so, so grateful for, and I tell our team this all the time, is that we’ve already succeeded. Going to community meetings, hearing people raise their hand, asking questions about the adjuster application or about their data, and I to emphasize that when you hear community members saying ‘our data’ and not an ask, but as something that they have obtained, it warms my heart, and it shows that we’re doing exactly what we said we wanted to do, which is to make sure that communities have the data that they deserve to create the future, the clean, healthy future that they desperately need.”.

Megan: Yeah, absolutely, what an incredible achievement. And what advice, finally, would you offer to other burgeoning entrepreneurs?

Darren: Yeah, I think really something you are passionate about. Repeat that point again, do something that you feel that you can really go through those pain points and struggles for, [because] you need some extra kick to get you through and navigate these challenges.

The second thing, and the most important thing that a lot of people take away is community, community, community. I wouldn’t be here today if I didn’t have people to call on when I’m at my lowest points, and call on people in my highest points. When people are celebrating you with your head up, and then when people are helping you put your chin up when your head’s down, I think it’s so, so critical. I found that here in Michigan, and also found it here in our community, right here in Detroit. Passion and finding a community that’s going to help get you through the journey is all it takes.

Megan: Fantastic. All great advice. Thank you ever so much, Darren.

Darren: Absolutely.

Megan: That was Darren Riley, the co-founder and CEO at JustAir whom I spoke with from Brighton, England.

That’s it for this episode of Business Lab. I’m your host, Megan Tatum. I’m a contributing editor and host for Insights, the custom publishing division of MIT Technology Review. We were founded in 1899 at the Massachusetts Institute of Technology, and you can find us in print on the web and at events each year around the world. For more information about us on the show, please check out our website at technologyreview.com.

This show is available wherever you get your podcasts. And if you enjoyed this episode, we hope you’ll take a moment to rate and review us. Business Lab is a production of MIT Technology Review. This episode was produced by Giro Studios. Thanks for listening.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

This content was researched, designed, and written entirely by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

Shaping the future with adaptive production

Adaptive production is more than a technological upgrade: it is a paradigm shift. This new frontier enables the integration of cutting-edge technologies to create an increasingly autonomous environment, where interconnected manufacturing plants go beyond the limits of traditional automation. Artificial intelligence, digital twins, and robotics are among the powerful tools manufacturers are using to create dynamic, intelligent systems that not only perform tasks, but also learn, make decisions, and evolve in real-time.

Taking this kind of adaptive approach can transform a manufacturer’s productivity, efficiency, and innovation. But beyond the factory, it also has the potential to deliver society-wide benefits, by bolstering economic growth locally, creating more attractive and accessible employment opportunities, and supporting a sustainability agenda.

As efforts to revive and modernize local manufacturing accelerate in regions around the world, including North America and Europe, adaptive production could help manufacturers overcome some of their biggest obstacles—firstly, attracting and retaining talent. Nearly 60% of manufacturers cited this as their top challenge in a 2024 US-based survey. Highly automated, technology-led adaptive production methods hold new promise for attracting talent to roles that are safer, less repetitive, and better paid. “The ideal scenario is one where AI enhances human capabilities, leads to new task creation, and empowers the people who are most at risk from automation’s impact on certain jobs, particularly those without college degrees,” says Simon Johnson, co-director of MIT’s Shaping the Future of Work Initiative.

Secondly, the digitalization of manufacturing—embedded in the very foundation of adaptive production technologies—allows companies to better address complex sustainability challenges through process and resource optimization and a better understanding of data. “By integrating these advanced technologies, we gain a more comprehensive picture across the entire production process and product lifecycle,” explains Jelena Mitic, head of technology for the Future of Automation at Siemens. “This will provide a much faster and more efficient way to optimize operations and ensure that all the necessary safety and sustainability requirements are met during quality control.”

Download the full report.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

This content was researched, designed, and written entirely by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

Finding value with AI automation

In June 2023, technology leaders and IT services executives had a lightning bolt headed their way when McKinsey published the “The economic potential of generative AI: The next productivity frontier” report. It echoed a moment from the 2010s when Amazon Web Services launched an advertising campaign aimed at Main Street’s C-suite: Why would any fiscally responsible exec allow their IT teams to spend capex for servers and software when AWS only cost 10 cents per virtual machine? 

Vendors understand that these kinds of reports and aggressive advertising around competitive risks projected onto an industry sector would drive many calls from boards to their C-suite, rolling from C-suite to their staff all asking, “What are we doing with AI?” When asked to “do something with AI,” technical leadership and their organizations promptly responded — sometimes begrudgingly and sometimes excitedly — for work-sanctioned opportunities to get their hands on a new technology. At that point, there was no time to sort between actual business returns from applying AI and “AI novelty” use cases that were more Rube Goldberg machines than tangible breakthroughs. 

Today’s opportunity: Significant automation gains 

When leaders respond to immediate panic, new business risks and mitigations often emerge.  Two recent examples highlight the consequences of rushing to implement and publish positive results from AI adoption. The Wall Street Journal reported in April 2025 on companies struggling to realize returns on AI. Just weeks later, it covered MIT’s retraction of a technical paper about AI where the results that led to its publication could not be substantiated.  

While these reports demonstrate the pitfalls of over-reliance on AI without common-sense guardrails, not all is off track in the land of enterprise AI adoption. Incredible results being found from judicious use of AI and related technologies in automating processes across industries. Now that we are through the “fear of missing out” stage and can get down to business, where are the best places to look for value when applying AI to automation of your business?  

While chatbots are almost as pervasive as new app downloads for mobile phones, the applications of AI realizing automation and productivity gains line up with the unique purpose and architecture of the underlying AI system they are built on. The dominant patterns where AI gains are realized currently boil down to two things: language (translation and patterns) and data (new format creation and data search).  

Example one: Natural language processing  

Manufacturing automation challenge: Failure Mode and Effects Analysis (FMEA) is both critical and often labor intensive. It is not always performed prior to a failure in manufacturing equipment, so very often FMEA occurs in a stressful manufacturing lines-down scenario. In Intel’s case, a global footprint of manufacturing facilities separated by large distances along with time zones and preferred language differences makes this even more difficult to find the root cause of a problem. Weeks of engineering effort are spent per FMEA analysis repeated across large fleets of tools spread between these facilities.  

Solution: Leverage already deployed CPU compute servers for natural language processing (NLP) across the manufacturing tool logs, where observations about the tools’ operations are maintained by the local manufacturing technicians. The analysis also applied sentiment analysis to classify words as positive, negative, or neutral. The new system performed FMEA on six months of data in under one minute, saving weeks of engineering time and allowing the manufacturing line to proactively service equipment on a pre-emptive schedule rather than incurring unexpected downtime.  

Financial institution challenge: Programming languages commonly used by software engineers have evolved. Mature bellwether institutions were often formed through a series of mergers and acquisitions over the years, and they continue to rely on critical systems that are based on 30-year-old programming languages that current-day software engineers are not familiar with. 

Solution: Use NLP to translate between the old and new programming languages, giving software engineers a needed boost to improve the serviceability of critical operational systems. Use the power of AI rather than doing a risky rewrite or massive upgrade. 

Example two: Company product specifications and generative AI models 

Sales automation challenge: The time it takes to reformat a company’s product data into a specific customer RFP format has been an ongoing challenge across industries. Teams of sales and technical leads spend weeks of work across different accounts reformatting the same root data between the preferred PowerPoint or Word document formats. The customer response times were measured in weeks, especially if the RFPs required legal reviews. 

Solution: By using generative AI combined with a data extraction and prompting technique called retrieval augmented generation (RAG), companies can rapidly reformat product information between different customer required RFP response formats. The time spent moving data between different documents and different document types only to find an unforced error in the move is reduced to hours instead of weeks.  

HR policy automation challenge: Navigating internal processes can be time consuming and confusing for both HR and employees. The consequences of misinterpretation, access outages, and personal information or private data being exposed are massively important to the company and the individual. 

Solution: Combine generative AI, RAG, and an interactive chatbot that uses employee-assigned assets to determine identity and access rights, provides employees interactive query-based chat formats to answer their questions in real time. 

Finding your best use cases for AI 

In a world where 80% to 90% of all AI proof of concepts fail to scale, now is the time to develop a framework that is based on caution. Consider starting with a data strategy and governance assessment. Then find opportunities to compare successful AI-based automation efforts at peer companies through peer discussions. Clear, rules-based policies and processes offer the best opportunities to begin a successful AI automation journey in your enterprise. Where you encounter disparate data sources (e.g., unstructured, video, structured databases) or unclear processes, maintain tighter human-in-the-loop decision controls to avoid unexpected data or token exposure and cost overruns. 

As the AI hype cycle cools and business pressure mounts, now is the time to become practical. Apply AI to well-defined use cases and begin unlocking the automation benefits that will matter not just in 2025, but for years to come.

This content was produced by Intel. It was not written by MIT Technology Review’s editorial staff.

Building an innovation ecosystem for the next century

Michigan may be best known as the birthplace of the American auto industry, but its innovation legacy runs far deeper, and its future is poised to be even broader. From creating the world’s largest airport factory during World War II at Willow Run to establishing the first successful polio vaccine trials in Ann Arbor to the invention of the snowboard in Muskegon, Michigan has a long history of turning innovation into lasting impact. 

Now, with the creation of a new role, chief innovation ecosystem officer, at the Michigan Economic Development Corporation (MEDC), the state is doubling down on its ambition to become a modern engine of innovation, one that is both rooted in its industrial past and designed for the evolving demands of the 21st century economy.  

“How do you knit together risk capital founders, businesses, universities, and state government, all of the key stakeholders that need to be at the table together to build a more effective innovation ecosystem?” asks Ben Marchionna, the first to hold this groundbreaking new position. 

Leaning on his background in hard tech startups and national security, Marchionna aims to bring a “builder’s thinking” to the state government. “I’m sort of wired for that—rapid prototyping, iterating, scaling, and driving that muscle into the state government ecosystem,” he explains.

But these efforts aren’t about creating a copycat Silicon Valley. Michigan’s approach is uniquely its own. “We want to develop the thing that makes the most sense for the ingredients that Michigan can bring to bear to this challenge,” says Marchionna. 

This includes cultivating both mom-and-pop businesses and tech unicorns, while tapping into the state’s talent, research, and manufacturing DNA. 

In an era where economic development often feels siloed, partisan, and reactive, Michigan is experimenting with a model centered on long-term value and community-oriented innovation. “You can lead by example in a lot of these ways, and that flywheel really can get going in a beautiful way when you step out of the prescriptive innovation culture mindset,” says Marchionna.

This episode of Business Lab is produced in partnership with the Michigan Economic Development Corporation.

Full Transcript 

Megan Tatum: From MIT Technology Review. I’m Megan Tatum, and this is Business Lab, the show that helps business leaders make sense of new technologies coming out of the lab and into the marketplace. 

Today’s episode is brought to you in partnership with the Michigan Economic Development Corporation. 

Our topic today is building a statewide innovation economy. Now, the U.S. state of Michigan has long been recognized as a leader in vehicle and mobility innovation. Detroit put it on the map, but did you know it’s also the birthplace of the snowboard or that the University of Michigan filed more than 600 invention disclosures in 2024, second only to the Massachusetts Institute of Technology, or that in the past five years, 40% of the largest global IPOs have been Michigan built companies?

Two words for you: innovation ecosystem. 

My guest is Ben Marchionna, chief innovation ecosystem officer at the Michigan Economic Development Corporation, the MEDC. 

Ben, thank you ever so much for joining us.

Ben Marchionna: Thanks, Megan. Really pleased to be here.

Megan: Fantastic. And just to set some context to get us started, I wondered if we could take a kind of high-level look at the economic development landscape. I mean, you joined the MEDC team last year as Michigan’s first chief innovation ecosystem officer. In fact, you were the first to hold such a role in the country, I believe. I wondered if you could talk a bit about your unique mission and how this economic development approach differs from efforts in other states.

Ben: Yeah, sure would love to. Probably worth pointing out that while I’ve been in this role for about a year now, it was indeed a first-of-its-kind role in the state of Michigan and first of its kind in the country. The slight difference in the terminology, chief innovation ecosystem officer, it differs a little bit from what folks might think of as a chief innovation officer. I’m not all that focused on driving innovation within government, which is what some other chief innovation officers would be focused on around the country. Instead, you can think of my role as Michigan’s chief architect for innovation, if you will. So, how do you knit together risk capital founders, businesses, universities, and state government, all of the key stakeholders that need to be at the table together to build a more effective innovation ecosystem? I talk a lot about building connective tissues that can achieve one plus one equals three outcomes.

Michigan’s got all kinds of really interesting ingredients and has the foundation to take advantage of the moment in a really interesting way over the next decades as we look to supercharge some of the growth of our innovation ecosystem development.

My charter is relatively simple. It’s to help make sure that Michigan wins in a now hyper-competitive global economy. And to do that, I end up being super focused on orienting us towards a growth and innovation-driven economy. That can mean a lot of different things, but I ultimately came to the MEDC and the role within the state with a builder’s mindset. My background is not in traditional economic development, it’s in not government at all. I spent the last 10 years building hard tech startups, one in Ann Arbor, Michigan, and another one in the Northern Virginia area. Before that, I spent a number of years at, think of it like, an innovation factory at Lockheed Martin Skunk Works in the Mojave Desert, working on national security projects.

I’m sort of wired for that, builder’s thinking, rapid prototyping, iterating, scaling, and driving that muscle into the state government ecosystem. I think it’s important that the government also figure out how to pull out all the stops and be able to move at the speed that founders expect. A bias towards action, if you will. And so this is ultimately what my mission is. There are a lot of real interesting things that the state of Michigan can bring to bear to building our innovation ecosystem. And I think, tackling it with this sort of a mindset, I am absolutely optimistic for the future that we’ve got ahead of us.

Megan: Fantastic. It almost sounds like your role is sort of building a statewide startup incubator of sorts. As we mentioned in the opening, Michigan actually has a really interesting innovation history even in addition to the advances in the automotive industry. I wondered if you could talk a bit more about that history and why Michigan, in particular, is poised to support that sort of statewide startup ecosystem.

Ben: Yeah, absolutely. And I would even broaden it. Building the startup ecosystem is one of the essential layers, but to be able to successfully do that, we have to bring in the research universities, we have to bring in the corporate innovation ecosystem, we have to bring in the risk capital, et cetera. So yes, absolutely, startups are important. And equally as important are all of these other elements that are necessary for a startup ecosystem to thrive, but are also the levers that are just sitting there waiting for us to pull them.

And we can get into some of the details over the course of our chat today on the auto industry and how this fits into it, but Michigan does a lot more than just automotive stuff. And you noted, I think, the surfboard as an example in the intro. Absolutely correct. We have a reputation as Motor City, but Michigan’s innovation record is a lot weirder in a fun way and richer than just cars.

Early 20th century, mostly industrial moonshot innovation. So first paved mile of concrete was in Detroit in 1909. A few years later, this is when the auto sector started to really come about with Henry Ford’s moving assembly line. Everyone tends to know about those details. But during World War II, Willow Run Airport sort of smack between Detroit and Ann Arbor, Michigan they had the biggest airplane factory in the world. They were cranking out B-24 bombers once every 63 minutes, and I’ve actually been to the office that Henry Ford and Charles Lindbergh shared. It’s still at the airport. And it was pretty cool because Henry Ford had a window built into the office that looked sort of around the corner so that he could tick off as airplanes rolled out of the hanger and make sure that they were following the same high rate production mentality that the auto sector was able to develop over the decades prior. 

And so they came in to help make sure that you could leverage that industrial sector to drive very rapid production, the at-scale mentality, which is also a really important part of the notion of re-industrialization that is taking hold across the country now. Happy to get into that a bit, but yeah, Willow Run, I don’t think most folks realize that that was the biggest airplane factory in the world sitting right here in Michigan.

And all of this provided the mass production DNA that was able to help build the statewide supplier base. And today, yes, we use that for automotive, EVs, space hardware, batteries, you name it. But this is the foundation, I think, that we’ve got to be able to build on in the future. In the few decades since you saw innovations in sports, space, advanced materials, it’s like the sixties to the eighties. You said the snowboard. That was invented in Muskegon on the west side of the state in 1965.

Dow Chemical’s here in a really big way. They’ve pioneered silicone and advanced plastics in Michigan. University of Michigan’s Dr. Thomas Francis is the world’s first successful polio vaccine trials that were pioneered out of Ann Arbor, and that Big 10 research horsepower that we’ve got in the state, between the University of Michigan, Michigan State University. We also have Wayne State University in Detroit, which is a powerhouse. And then Michigan Tech University in the Upper Peninsula just recently became an R1 research institution, which essentially means those top-tier research powerhouses and that culture of tinkering matter a lot today.

I think in more recent history, you saw design and digital innovations emerge. I don’t think a lot of people appreciate that Herman Miller and Steelcase reinvented office ergonomics on the west side of the state, or that Stryker is based in Kalamazoo. They became a global medical device powerhouse over the last couple of decades, too. Michigan’s first unicorn, Duo Security, the two-factor authentication among many other things that they do there, was sold to Cisco in 2018 for 2.35 billion.

Like I said, the first unicorn in the few years since we’ve had another 10 unicorns. And I think probably what would be surprising to a lot of people is it’s in sectors well beyond mobility, it’s marketplace like StockX, FinTech, logistics, cybersecurity, of course. It’s a little bit of everything, and I think that goes to show that some of the fabric that exists within Michigan is a lot richer than what people think of, Motor City. We can scale software, we can scale life sciences innovation. It’s not just metal bending, and I talked about re-industrialization earlier. So I think about where we are today, there’s a hard tech renaissance and a broad portfolio of other high-growth sectors that Michigan’s poised to do really well in, leveraging all of that industrial base that has been around for the last century. I’m just super excited about the future and where we can take things from here.

Megan: I mean, genuinely, a really rich and diverse history of innovation that you’ve described there.

Ben: That’s right.

Megan: And last year, when Michigan’s Governor Whitmer announced this new initiative and your position, she noted the need to foster this sort of culture of innovation. And we hear that a lot that terminal in the context of company cultures. It’s interesting to hear in the context of a U.S. state’s economy. I wonder what your strategy is for building out this ecosystem, and how do you foster a state’s innovation culture?

Ben: Yeah, it’s an awesome point, and I think I mentioned earlier that I came into the role with this builder’s mentality. For me, this is how I am wired to think. This is how a lot of the companies and other founders that I spent a lot of time with, this is how they think. And so bringing this to the state government, I think of Blue Origin, Jeff Bezos’ space company, their motto, the English translation at least of it, is “Step by Step, Ferociously.” And I think about that as a lot as a proxy for how I do that within the state government. There’s a lot of iterative work that needs to happen, a lot of coaching and storytelling that happens to help folks understand how to think with that builder’s mindset. The wonderful news is that when you start having that conversation, this is one of those in these complicated political times, this is a pretty bipartisan thing, right?

The notion of how to build small businesses that create thriving main street communities while also supporting high-growth, high-tech startups that can drive prosperity for all, and population growth, while also being able to cover corporate innovation and technology transfer out of universities. All of these things touch every corner of the state.

And Michigan’s a surprisingly large and very geographically diverse state. Most of the things that we tend to be known for outside the state are in a pretty small corner of Southeast Michigan. That’s the Motor City part, but we do a lot and we have a lot of really interesting hubs for innovation and hubs for entrepreneurship, like I said, from the small mom-and-pop manufacturing shop or interest in clothing business all the way through to these insane life sciences innovations being spun out of the university. Being able to drive this culture of innovation ends up being applicable really across the board, and it just gets people really fired up when you start talking about this, fired up in a good way, which is, I think, what’s really fantastic.

There’s this notion of accelerating the talent flywheel and making sure that the state can invest in the cultivation of really rich communities and connections, and this founder culture. That stuff happens organically, generally, and when you talk about building startup ecosystems, it’s not like the state shows up and says, “Now you’re going to be more innovative and that works.” That is not the case.

And so to be able to develop those things, it’s much more about this notion of ecosystem building and getting the ingredients and puzzle pieces in the right place, applying a little bit of funding here and there, or loosening a restriction here or there, and then letting the founders do what they do best, which is build. And so this is what I think I end up being super passionate about within the state. You can lead by example in a lot of these ways, and that flywheel that I mentioned really can get going in a beautiful way when you step out of the prescriptive innovation culture mindset.

Megan: And given that role, I wonder what milestones the campaign has experienced in your first year? Could you share some highlights and some developing projects that you’re really excited about?

Ben: We had a recent one, I think that was pretty tremendous. Just a couple of months ago, Governor Whitmer signed into law a bipartisan legislation called the Michigan Innovation Fund. This was a multi-year effort that resulted in the state’s biggest investment in the innovation ecosystem development in over two decades. A lot of this funding is going to early stage venture capital firms that will be able to support the broad seeding of new companies and ideas, keep talent within the state from some of those top tier research institutions, bring in really high quality companies that early stage, growth stage companies from out of state, and then develop or supercharge some of that innovation ecosystem fabric that ties those things together. So that connective tissue that I talked about, and that was an incredible win to launch the year with.

This was just back in January, and now we’re working to get some of those funds out over the course of the next month or two so we can put them to use. What was really interesting about that was, it wasn’t just a top-down thing. This was supported from the top all the way up to and including Governor Whitmer. I mentioned bipartisan support within Michigan’s legislature and then bottom-up from all of the ecosystem partners, the founders, the investors advocating as a whole block, which I think is really powerful. Rather than trying to go for one-off things, this huge coalition of the willing got together organically and advocated for, hey, this is why this is such a great moment. This is the time to invest. And Governor Whitmer and the legislators, they heard that call, and we got something done, and so that happened relatively quickly. Like I said, biggest investment in the last two decades, and I think we’re poised to have some really great successes in the coming year as well.

Another really interesting one that I haven’t seen other states do yet, Governor Whitmer, around a year ago, signed an executive order called the Infrastructure for Innovation. Essentially, what that does is it opens up state department and agency assets to startups in the name of moving the ball forward on innovation projects. And so if you’re a startup and you need access to some very hard-to-find, very expensive, maybe like a test facility, you can use something that the state has, and all of the processes to get that done are streamlined so that you’re not beating your head against a wall. Similarly, the universities and even federal labs and corporate resources, while an executive order can’t compel those folks to do that, we’ve been finding tremendous buy-in from those stakeholders who want to volunteer access to their resources.

That does a lot of really good things, certainly for the founders, that provides them the launchpad that they need. But for those corporations and universities, and whatnot, a lot of them have these very expensive assets sitting around wildly underutilized, and they would be happy to have people come in and use them. That also gives them exposure to some of the bleeding-edge technology that a lot of these startups today are developing. I thought that was a really cool example of state government leadership using some of the tools that are available to a governor to get things moving. We’ve had a lot of early wins with startups here that have been able to leverage what that executive order was able to do for them.

Here we are talking about the MIT Technology Review to tie in an MIT piece here, we also started a Team Michigan for MIT’s REAP program. It’s the Regional Entrepreneurship Acceleration Program, and this is one of the global thought leaders on best practices for innovation ecosystem development. And so we’ve got a cohort of about a dozen key leaders from across all of those different stakeholders who need to have a seat at the table for this ecosystem development.

We go out to Cambridge twice a year for a multi-day workshop, and we get to talk about what we’ve learned as best practices, and then also learn from other cohorts from around the world on what they’ve done that is great. And then also get to hear some of the academic best practices that the MIT faculty have discovered as part of this area of expertise. And so that’s been a very interesting way for us to be able to connect outside of the state government boundaries, if you will. You sort of get out there and see where the leading edge is and then come back and be able to talk about the things that we learned from all of these other global cohorts. So always important to be focused on best practices when you’re trying to do new things, especially in government.

Megan: Sounds like there are some really fantastic initiatives going on. It sounds like a very busy first year.

Ben: It’s been a very busy first year couldn’t be more thrilled about it.

Megan: Fantastic. And in early 2023, I know that Newlab partnered with Michigan Central to establish a startup incubator too, which brought in more than a hundred startups just in its first 14 months. I wonder if you could talk a bit about how the incubator fits in with the statewide startup ecosystem and the importance of partnerships, too, for innovation.

Ben: Yeah, a key element, and I think the partnerships piece is essential here. Newlab is one of the larger components of the Southeast Michigan and especially the Detroit innovation ecosystem development. They will hit their two-year launch anniversary in just a couple of weeks, here I think. This will be mid-May, it will be two years and in that time, they’ve now got 140 plus startups all working out of their space, and Newlab they’re actually headquartered in Brooklyn, New York, but they run this big startup accelerator incubator out of Detroit as well and so this is sort of their second flagship location. They’ve been a phenomenal partner, and so speaking of the partnerships, what do those do?

They de-risk the technologies to help enable broader adoptions. Corporations can provide early revenues, the state can provide non-dilutive grant matching. Universities can bring IP and this renewable source of talent generation, and being able to stitch together all of those pieces can create some really interesting unlocks for startups to grow. But again, also this broader entrepreneurship and innovation ecosystem to really be able to thrive.

Newlab has been thrilled with their partnership in Southeast Michigan, and I think it’s a model that can be tailored across the state so that, depending on what assets are available in your backyard, you can make sure that you can best harness those for future growth.

Megan: Fantastic. What’s the long-term vision for the state’s innovation landscape when you think about it in five, 10 years from now? What do you envisage?

Ben: Amazing question. This is probably what I get most excited about. I think earlier we talked about the Willow Run B-24 bomber plant. That is what made Michigan known as the arsenal of democracy back in the day. I want Michigan to be the arsenal of innovation. We’re not trying to recreate a Silicon Valley. Silicon Valley does certain things, not trying to recreate what El Segundo wants to do in hard tech or New York City in FinTech, and all of these other things. We want to develop the thing that makes the most sense for the ingredients that Michigan can bring to bear to this challenge.

I think that becoming the Midwest arsenal of innovation, that’s something that Michigan is very well poised to use as a springboard for the decades to come. I want us to be the default launch pad for building a hard tech company, a life sciences company, an agricultural tech company. You name it. If you’ve got a design prototype and want to mass produce something, don’t want to hop coast, you want to be somewhere that has a tremendous quality of life, an affordable place, somewhere that government is at the table and willing to move fast, this is a place to do that.

That can be difficult to do in some of the more established ecosystems, especially post-covid, as a lot of them are going through really big transition periods. Michigan’s already a top 10 state for business in the next 10 years. I want us to be a top 10 state for employment, top 10 state for household median income for post-secondary education attainment, and net talent migration. Those are my four top tens that I want to see in the next 10 years. And we covered a lot of topics today, but I think those are the reasons that I am super optimistic about being able to accomplish those.

Megan: Fantastic. Well, I’m tempted to move to Michigan, so I’m sure plenty of other people will be now, too. Thank you so much, Ben. That was really fascinating.

Ben: Thanks, Megan. Really delighted to be here.

Megan: That was Ben Marchionna, chief innovation ecosystem officer at the Michigan Economic Development Corporation, whom I spoke with from Brighton, England. 

That’s it for this episode of Business Lab. I’m your host, Megan Tatum. I’m a contributing editor and host for Insights, the custom publishing division of MIT Technology Review. We were founded in 1899 at the Massachusetts Institute of Technology, and you can find us in print on the web and at events each year around the world. For more information about us and the show, please check out our website at technologyreview.com.

This show is available wherever you get your podcasts, and if you enjoy this episode, we hope you’ll take a moment to rate and review us. Business Lab is a production of MIT Technology Review. This episode was produced by Giro Studios. Thanks ever so much for listening.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

This content was researched, designed, and written entirely by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.

Producing tangible business benefits from modern iPaaS solutions

When a historic UK-based retailer set out to modernize its IT environment, it was wrestling with systems that had grown organically for more than 175 years. Prior digital transformation efforts had resulted in a patchwork of hundreds of integration flows spanning cloud, on-premises systems, and third-party vendors, all communicating across multiple protocols. 

The company needed a way to bridge the invisible seams stitching together decades of technology decisions. So, rather than layering on yet another patch, it opted for a more cohesive approach: an integration platform as a service (iPaaS) solution, i.e. a cloud-based ecosystem that enables smooth connections across applications and data sources. By going this route, the company reduced the total cost of ownership of its integration landscape by 40%.

The scenario illustrates the power of iPaaS in action. For many enterprises, iPaaS turns what was once a costly, complex undertaking into a streamlined, strategic advantage. According to Forrester research commissioned by SAP, businesses modernizing with iPaaS solutions can see a 345% return on investment over three years, with a payback period of less than six months.

Agile integration for an AI-first world

In 2025, the business need for flexible and friction-free integration has new urgency. When core business systems can’t communicate easily, the impacts ripple across the organization: Customer support teams can’t access real-time order statuses, finance teams struggle to consolidate data for monthly closes, and marketers lack reliable insights to personalize campaigns or effectively measure ROI.

A lack of high-quality data access is particularly problematic in the AI era, which depends on current, consistent, and connected data flows to fuel everything from predictive analytics to bespoke AI copilots. To unleash the full potential of AI, enterprises must first solve for any bottlenecks that prevent information from flowing freely across their systems. They must also ensure data pipelines are reliable and well-governed; when AI models are trained on inconsistent or outdated data, the insights they generate can be misleading or incomplete—which can undermine everything from customer recommendations to financial forecasting.

iPaaS platforms are often well-suited for accomplishing this across dynamic, distributed environments. Built as cloud-native, microservices-based integration hubs, modern iPaaS platforms can scale rapidly, adapt to changing workloads, and support hybrid architectures without adding complexity. They also help simplify the user experience for everyday business users via low-code functionalities that allow both technical and non-technical employees to build workflows with simple drag-and-drop or click-to-configure interfaces.

This self-service model has practical, real-world applications across business functions: For instance, customer service agents can connect support ticketing systems with real-time inventory or shipping data, finance departments can link payment processors to accounting software, and marketing teams can sync CRM data with campaign platforms to trigger personalized outreach—all without waiting for IT to come to the rescue.

Architectural foundations for fast, flexible integration

Several key architectural elements make the agility associated with iPaaS solutions possible:

  1. API-first design that treats every connection as a reusable service
  2. Event-driven capabilities that enable real-time responsiveness
  3. Modular components that can be mixed and matched to address specific business scenarios

These principles are central to making the transition from “spaghetti architecture” to “integration fabric”—a shift from brittle point-to-point connections to intelligent, policy-driven connectivity that spans multidimensional IT environments.

This approach means that when a company wants to add a new application, onboard a new partner, or create a new customer experience, they’re able to do so by tapping into existing integration assets rather than starting from scratch—which can lead to dramatically faster deployment cycles. It also helps enforce consistency and, in some cases, security and compliance across environments (role-based access controls and built-in monitoring capabilities, for example, can allow organizations to apply standards more uniformly).

Further, studies suggest that iPaaS solutions enable companies to unlock new revenue streams by integrating previously siloed data and processes. Forrester research found that organizations adopting iPaaS solutions stand to generate nearly $1 million in incremental profit over three years by creating new digital services, improving customer experiences, and automating revenue-generating processes that were previously manual.

Where iPaaS is headed: convergence and intelligence

All this momentum is perhaps one of the reasons why the global iPaaS market, valued at approximately $12.9 billion in 2024, is projected to reach more than $78 billion by 2032—with growth rates exceeding 25% annually.

This trajectory is contingent on two ongoing trends: the convergence of integration capabilities into broader application development platforms, and the infusion of AI into the integration lifecycle.

Today, the boundaries between iPaaS, automation platforms, and AI development environments are blurring as vendors create unified solutions that can handle everything from basic data synchronization to complex business processes. 

AI and machine learning capabilities are also being embedded directly into integration platforms. Soon, features like predictive maintenance of integration flow or intelligent routing of data based on current conditions are likely to become table stakes. Already, integration platforms are becoming smarter and more autonomous, capable of optimizing themselves and, in some cases, even initiating self-healing actions when problems arise.

At the same time, this shift is transforming how businesses think about integration as a dynamic enabler of AI strategy. In the near future, robust integration frameworks will be essential to operationalize AI at scale and feed these systems the rich, contextual data they need to deliver meaningful insights.

Building integration as competitive advantage

In addition to the retail modernization story detailed earlier, a few more real-world examples highlight the potential of iPaaS:

  • A chemicals manufacturer migrated 363 legacy interfaces to an iPaaS platform and now spins up new integrations 50% faster.
  • A North American bottling company reduced integration runtime costs by more than 50% while supporting 12 legal entities on a single cloud ERP instance through common APIs.
  • A global shipping-technology firm connected its CRM and third-party systems via cloud-based iPaaS solutions, enabling 100% touchless order fulfillment and a 95% cut in cost centers after a nine-month rollout in its first region.

Taken together, these examples make a compelling case for integration as strategy, not just infrastructure. They reflect a shift in mindset, where integration is democratized and embedded into how every team, not just IT, gets work done. Companies that treat integration as a core capability versus an IT afterthought are reaping tangible, enterprise-wide benefits, from faster go-to-market timelines and reduced operational costs to fully automated business processes.

As AI reshapes business processes and customer standards continue to climb, enterprises are realizing that integration architecture determines not only what they can build today, but how quickly they can adapt to whatever comes tomorrow.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

This content was researched, designed, and written entirely by human writers, editors, analysts, and illustrators. This includes the writing of surveys and collection of data for surveys. AI tools that may have been used were limited to secondary production processes that passed thorough human review.