How exosomes could become more than just an “anti-aging” fad

This article first appeared in The Checkup, MIT Technology Review’s weekly biotech newsletter. To receive it in your inbox every Thursday, and read articles like this first, sign up here.

Over the past month or so, I’ve been working on a story about exosomes. You might have seen them advertised—they’re being touted as a hot new beauty treatment, a fountain of youth, and generally a cure-all therapy for a whole host of ailments.

Any cell biologist, though, will tell you what exosomes really are: tiny little blobs that bud off from cells and contain a mixture of proteins and other components. We’re not entirely clear what those components are or what they do, despite the promises made by medspas and cosmetic clinics charging thousands of dollars for exosome “therapies.” As one recipient of an exosome treatment told me, “I feel like it’s a little bit of health marketing bullshit.”

But there is some very exciting scientific research underway to better understand exactly what exosomes do. Scientists are exploring not only how these tiny particles might help cells communicate, but also how they might be used to diagnose or treat diseases. One company is trying to use exosomes to deliver drugs to the brains of people with rare neurological disorders.

It might take longer for these kinds of exosome applications to get to the clinic, but when they do, at least they’ll be evidence based.

Exosomes are a type of extracellular vesicle. This is a scientific way of saying they are basically little packages that bud off from cells. They were once thought to contain cellular garbage, but now scientists believe they convey important signals between cells and tissues.

Exactly what those signals are is still being figured out.  The contents of exosomes from cancer cells will probably be somewhat different to those from healthy cells, for example.

Because of that, many scientists hope that exosomes could one day be used to help us diagnose diseases. In theory, you could isolate exosomes from a blood sample, examine their contents, and figure out what might be going on in a person’s cells. Exosomes might provide clues as to how stressed or close to death a cell is. They might indicate the presence of a tumor.

Raghu Kalluri, a cancer biologist at MD Anderson Cancer Center in Houston, is one of the researchers exploring this possibility. “I believe that exosomes are likely providing a forensic fingerprint of what the cells are undergoing,” he says.

But understanding these signals won’t be straightforward. Exosomes from cancer cells might send signals to surrounding cells in order to “subjugate” them into helping the cancer grow, says Kalluri. Cells around a tumor might also send distress signals, alerting the immune system to fight back against it. “There’s definitely a role for these exosomes in cancer progression and metastasis,” he says. “Precisely what [that role is] is an active area of research right now.”

Exosomes could also be useful for delivering drug treatments. After all, they are essentially little packages of proteins and other matter that can be shuttled between cells. Why not fill them with a medicine and use them to target specific regions of the body?

Because exosomes are made in our bodies, they are less likely to be seen as “foreign” and rejected by our immune systems. And the outer layer of an exosome can serve as a protective coat, shielding the drug from being degraded until it reaches its destination, says James Edgar, who studies exosomes at the University of Cambridge. “It’s a really attractive method for drug delivery,” he says.

Dave Carter is one scientist working on it. Carter and his colleagues at Evox Therapeutics in Oxford, UK, are engineering cells to produce compounds that might help treat rare neurological diseases. These compounds could then be released from the cells in exosomes.

In their research, Carter and his colleagues can change almost everything about the exosomes they study. They can alter their contents, loading them with proteins or viruses or even gene-editing therapies. They can tweak the proteins on their surfaces to make them target different cells and tissues. They can control how long exosomes stay in an animal’s circulation.

“I always used to love playing with Lego,” he adds. “I feel like I’m playing with Lego when I’m working with exosomes.”

Others are hopeful that exosomes themselves hold some kind of therapeutic value. Some hope that exosomes derived from stem cells, for example, might have some regenerative capacity.

Ke Cheng at Columbia University in New York is interested in the idea of using exosomes to treat heart and lung conditions. Several preliminary studies suggest that exosomes from heart and stem cells might help animals like mice and pigs recover from heart injuries, such as those caused by a heart attack.

There are certainly plenty of clinical trials of exosomes underway. When I searched for “exosomes” on clinicaltrials.gov, I got over 400 results. These are early-stage trials, however—and are of variable quality.

Still, it’s an exciting time for exosome research. “It’s a growing field … I think we will see a lot of exciting science in the next five years,” says Cheng. “I’m very optimistic.”


Now read the rest of The Checkup

Read more from MIT Technology Review’s archive

You can read the piece about the costly exosome treatments being sold in aesthetic clinics and medspas in my longer piece, which was published earlier this week. 

It can be difficult to establish credibility in a medical field when you’re being undercut by clinics selling unapproved treatments and individuals making outlandish claims. Just ask the doctors and scientists trying to legitimize longevity medicine

Some treatments can take off culturally without the backing of rigorous evidence, only to go up in flames when the trial results come in. We saw this earlier this year, when FDA advisors rejected the use of MDMA (or ecstasy) for post-traumatic stress disorder (PTSD) owing to “significant confounders” in the trials. 

For some people, unproven treatments might represent a last hope for survival. In those cases, how do we balance access to experimental medicine with the need to protect people who are vulnerable?

Stem cells from human embryos promised to “launch a medical revolution in which ailing organs and tissues might be repaired” when they were isolated just over 25 years ago. So why haven’t they?  

From around the web

Having a disability shouldn’t prevent you from getting married. But that’s exactly the conundrum facing some people in the US, as this heartbreaking short documentary shows. (STAT)

A Neuralink rival says its eye implant restored vision in blind people. Science Corporation’s retinal implant enabled some legally blind individuals to read from a book, play cards, and fill out crossword puzzles. (Wired)

Women in Texas are dying after doctors delay treating them for miscarriages. Doctors treating Josseli Barnica waited 40 hours for the heart of her fetus to stop beating, despite the fact that miscarriage was “inevitable.” Her husband says doctors worried that “it would be a crime to give her an abortion.” She died of a preventable infection three days later. (ProPublica)

Between 30% and 50% of twins share a secret language or mode of communication, a phenomenon known as cryptophasia. The Youlden twins call theirs Umeri. (BBC Future)

Can a machine express fear? Try your hand at creating AI-generated images frightening enough to “spook the machine” as part of a project to explore how machines might express humanlike emotions. It is Halloween, after all. (Spook the Machine)

The Download: OpenAI launches search, and AI-generated video games

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

OpenAI has brought a new web search tool to ChatGPT

The news: ChatGPT can now search the web for up-to-date answers to a user’s queries. Previously it was restricted to generating answers from its training data, and had limited web search capabilities. But now, ChatGPT will automatically search the web in response to queries about recent information such as sports, stocks, or news of the day, and can deliver rich multi-media results.

How to use it: The feature is available now for the chatbot’s paying users, but OpenAI intends to make it available for free later, even when people are logged out. It also plans to combine search with its voice features.

The context: OpenAI is the latest tech company to debut an AI-powered search assistant, challenging similar tools from competitors such as Google, Microsoft, and startup Perplexity. However, none of these tools are immune from the persistent tendency of AI language models to make things up or get them wrong. Read the full story.

—Melissa Heikkilä and Mat Honan

AI search could break the web

—Benjamin Brooks is a fellow at the Berkman Klein Center at Harvard scrutinizing the regulatory and legislative response to AI. 

At its best, AI search can better infer a user’s intent, amplify quality content, and synthesize information from diverse sources. But if AI search becomes our primary portal to the web, it threatens to disrupt an already precarious digital economy. 

Today, the production of content online depends on a fragile set of incentives tied to virtual foot traffic: ads, subscriptions, donations, sales, or brand exposure. By shielding the web behind an all-knowing chatbot, AI search could deprive creators of the visits and “eyeballs” they need to survive. Here’s what the industry should do to make AI search sustainable.

This AI-generated Minecraft may represent the future of real-time video generation

When you walk around in a version of the video game Minecraft from the AI companies Decart and Etched, it feels a little off. Sure, you can move forward, cut down a tree, and lay down a dirt block, just like in the real thing. If you turn around, though, the dirt block you just placed may have morphed into a totally new environment. That doesn’t happen in Minecraft. But this new version is entirely AI-generated, so it’s prone to hallucinations. Not a single line of code was written.

For Decart and Etched, this demo is a proof of concept. But they believe that, with innovations in chip design and further improvements, there’s no reason it won’t soon be possible to develop a high-fidelity version of Minecraft, or really any game, using AI. Read the full story

—Scott J Mulligan

Read next: AI-powered NPCs that don’t need a script could make games—and other worlds—deeply immersive. Read our feature about how generative AI could reinvent what it means to play.

How exosomes could become more than just an “anti-aging” fad

—Jessica Hamzelou 

Over the past month or so, I’ve been working on a story about exosomes. They’re being touted as a hot new beauty treatment, a fountain of youth, and generally a cure-all therapy for a whole host of ailments.

Any cell biologist, though, will tell you what exosomes really are: tiny little blobs that bud off from cells and contain a mixture of proteins and other components. We’re not entirely clear what those components are or what they do, despite the promises made by medspas and cosmetic clinics charging thousands of dollars for exosome “therapies.” 

However, there is some very exciting scientific research underway to better understand exactly what exosomes do. It might take longer for these kinds of exosome applications to get to the clinic, but when they do, at least they’ll be evidence based. Read all about what’s going on

This story is from The Checkup, our weekly newsletter giving you the inside track on all things biotech and health. Sign up to receive it in your inbox every Thursday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 As the US election looms, social media platforms have given up moderating
Efforts to fight falsehoods have drastically backslid since 2020. (Wired $)
Young voters are encountering Trump’s ‘grab them’ comment for the first time on TikTok. (WP $) 
+ Ignore the noise—the US election system is actually stronger than ever, experts say. (CNET)
 
2 AI policy is something Harris and Trump broadly agree on
On the surface, they look miles apart. But dig into their track records, and there are lots of similarities. (The Atlantic $)
Investors are getting tired of waiting for returns on their AI investments. (Quartz $)
What even is AI? No one seems to agree—and that’s a problem. (MIT Technology Review)
 
3 Inside Elon Musk’s grand plan to remake the US government
If he gets his promised role as efficiency ‘tsar’, he plans to go on a slashing and burning spree. (WP $)
 
4 Outside the US, the world is increasingly using Chinese technology
Despite US sanctions, it dominates fields like drones, solar panels, and electric vehicles. (Bloomberg $)
Chinese sanctions are causing a supply chain crisis for Skydio, the US’s largest drone maker. (FT $)
BYD posted higher quarterly revenues than Tesla for the first time. (FT $)
+ What’s next for drones. (MIT Technology Review)
 
5 Here’s how to make all the political text messages go away
Whatever you do, do not actually reply ‘Stop’ (seriously). (WSJ $)
 
6 Amazon workers are furious over its return-to-office policy
They say the company is failing to provide evidence to back it up, and misrepresenting their views. (Reuters $)
 
7 Hundreds of Dubliners turned up for a fake AI-generated Halloween parade 🎃
We can expect to see more and more examples like this, of AI fakery spilling over into the physical world. (Metro)
 
8 Ghost jobs are haunting tech workers
Fake jobs posted by real companies are growing irritation for people seeking work. (SFGate)
 
9 ‘Cloud-milking’ is a new zero-energy way to extract water from fog ☁💧
It’s been successfully tested in the Canary Islands, but it could help other areas recovering from natural disasters. (The Guardian)
 
10 Your wall paints could soon do much more than look pretty
Innovators are working on paints that can peel off, resist dirt, and even provide insulation. (BBC)

Quote of the day

We’re going to add a whole new category of content, which is AI generated or AI summarized content or kind of existing content pulled together by AI in some way. And I think that that’s going to be just very exciting.

—Mark Zuckerberg says we can expect our timelines to be filled with more and more AI slop during a call with investors, 404 Media reports. 

 The big story

Why Generation Z falls for online misinformation

teenage girls on their phones

GETTY

June 2021

In November 2019, a TikTok video claiming that if Joe Biden is elected president of the United States, “trumpies” will commit mass murder of LGBT individuals and people of color rapidly went viral. It was viewed, shared, liked and commented on by hundreds of thousands of young people.

Clearly, the claims were false. Why, then, did so many members of Generation Z—a label applied to people aged roughly 9 to 24, who are presumably more digitally savvy than their predecessors—fall for such flagrant misinformation? The answer is complex, but may partly lie in a sense of common identity with the person who shared it in the first place. Read the full story.

—Jennifer Neda John

We can still have nice things

A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line or tweet ’em at me.)

+ Here are some words to warm you up on this first day of November.

+ Becky Barnicoat’s comics always make me laugh.

+ If you were also obsessed with Tom and Greg in Succession, you’ll enjoy this.  

+ Let’s hear it for Missy Elliott—here’s why she’s such a peerless entertainer. ($)

The ‘Why’ of Man Flow Yoga

To Dean Pohlman, long-term business success stems from a purpose. His is to help men improve their health and fulfillment through fitness and personal connections. That’s the mission of Man Flow Yoga, the company he founded in 2012, which offers memberships to workout programs and a paid community.

Pohlman, a former college lacrosse player, is an authority on yoga instruction for men and a published author on the topic.

He first appeared on the podcast in 2021. In this our second conversation, he shares client success stories, YouTube tactics, and the “why” behind his business.

The entire audio of our discussion is embedded below. The transcript is edited for length and clarity.

Eric Bandholz: Give us a quick rundown on who you are.

Dean Pohlman: I own a company called Man Flow Yoga. We sell memberships to Yoga workout programs for men.

I’m a former collegiate lacrosse player. I discovered yoga by accident but noticed its benefits after consistent practice. However, I saw that men weren’t engaging with it much, especially because it wasn’t presented in a way that resonated with them. So, I created a brand focusing on fitness-oriented yoga tailored for men. I initially launched a YouTube channel and a Facebook page.

Over time, I developed paid membership workouts for men — primarily those in their 40s, 50s, and 60s. They found they couldn’t do their regular workouts due to aging and needed to focus on flexibility and foundational strength. Our programs help with flexibility and alleviate pain in, typically, the lower back, shoulders, and knees. The ultimate goal is to enable men to stay active and independent as long as possible, whether playing with their kids or staying mobile as they age.

I’ve been interviewing members for our podcast, “The Better Man.” One memorable story is from a guy who weighed 300 pounds at the onset of Covid. He started a yoga program alongside daily dog walks and lost 75 pounds within a year. What stands out from these stories is the consistency people find in exercise. They enjoy it and feel good afterward, which encourages them to continue. This creates a ripple effect, where they start improving other areas of their lives like diet or adding in more physical activities.

Bandholz: What do your workout programs look like?

Pohlman: They can be as few as two to three times per week or as many as five or six. Our sessions aren’t long — typically 30 to 40 minutes. We have beginner programs that start at 15 to 20 minutes. People start noticing changes after just a few weeks, especially in how they feel.

For example, back pain disappears. These physical improvements motivate people to stay consistent. When you feel better and have more energy, it’s easier to continue instead of focusing solely on aesthetics, which takes much longer to notice.

Bandholz: You’ve done a great job of building a community.

Pohlman: I’m proud of the Facebook Group we’ve built, though it took a lot of time. It’s a supportive community of about 7,000 men who aren’t afraid to be vulnerable and share personal struggles. When someone posts about not being consistent with workouts, they’re met with understanding, not judgment. People relate to the same struggles, which fosters a sense of camaraderie.

I launched the group in 2013, and new members are always welcome. However, to maintain its quality, we keep the group exclusive to paying members — whether they join a challenge, sign up for a full membership, or purchase a book.

We consistently remind members about the community through emails, video mentions, and our 90-day onboarding series. The ongoing engagement keeps people connected and accountable.

Bandholz: How’s your YouTube channel performing?

Pohlman: Despite having over 500,000 subscribers, engagement is relatively low, although new videos typically get 3,000 to 10,000 views in the first week. Some go viral. Our morning yoga videos have recently gained traction. Short-form content is also helping with the algorithm. We went from gaining about 3,000 subscribers monthly to 10,000 last month. Certain topics, like sexual wellness, perform exceptionally well.

Bandholz: Do you collaborate with other brands?

Pohlman: Collaborations need to feel organic. I prefer working with people I genuinely connect with and would hang out with outside of business. One example is Anthony Balduzzi from Fit Father Project. We’ve been collaborating for about two years; our products complement each other. Beyond business, he’s a friend. These types of authentic relationships work well for long-term success, and that’s the approach I take.

Bandholz: What’s your long-term vision for Man Flow Yoga?

Pohlman: I want the business to expand beyond yoga into a broader men’s wellness brand. I’ve started introducing mental and emotional wellness topics on the podcast, but I want to incorporate more of that. We currently offer structured programs via an app and website, but everything is self-paced. I want to introduce more guided support — something more hands-on. While we have customer support and a Facebook Group, a more direct assistance model could benefit our members.

Bandholz: What’s the “why” behind your business?

Pohlman: Many men haven’t done the introspective work to understand their desires and what drives them. It’s about recognizing that the things I truly want — family, freedom, joy — are already within reach. I don’t need to wait for a business milestone to achieve them.

Most men believe they must accomplish something before feeling fulfilled, but that’s a trap. Once you realize you can have what you want, life becomes easier. Authenticity is key. People can sense inauthenticity, and I believe businesses built on genuine connections and purpose are more successful in the long run.

Bandholz: Where can people follow you?

Pohlman: Visit ManFlowYoga.com to get started. You can find me on all the major platforms — YouTube, Instagram, Facebook, and TikTok.

Google Updates Crawl Budget Best Practices via @sejournal, @MattGSouthern

Google has updated its crawl budget guidelines, stressing the need to maintain consistent link structures between mobile and desktop websites.

  • Large websites must ensure mobile versions contain all desktop links or risk slower page discovery.
  • The update mainly impacts sites with over 10,000 pages or those experiencing indexing issues.
  • Link structure consistency across mobile and desktop is now a Google-recommended best practice for crawl budget optimization.
Automattic’s Response To WP Engine Lawsuit Reframes Narrative via @sejournal, @martinibuster

Lawyers for Matt Mullenweg and Automattic filed a motion to dismiss the lawsuit from WP Engine, offering a different perspective on the dispute’s underlying causes.

The motion to dismiss claims that the one causing harm isn’t Mullenweg and Automattic but WP Engine, asserting that WP Engine is compelling the defendant to provide resources and support free of charge as well as to restrict the Mullenweg’s ability to express his opinions about WP Engine’s practices.

The motion to dismiss begins by accuses WP Engine of selectively choosing recent events as basis for their complaint. It then fills in the parts that were left out, beginning with the founding of WordPress over two decades ago when Matt co-founded a way to create websites that democratized Internet publishing in the process. The motion outlines how his organization devoted thousands of person-years to growing the platform, eventually getting it to a point where it now generates an estimated $10 billion dollars per year for thousands of companies and freelancers.

The point of the first part of the motion is to explain that Mullenweg and Automattic support the open source WordPress project because the project depends on a “symbiotic” relationship between the WordPress community and those who are a part of it, including web hosts like WP Engine.

“But the success and vitality of WordPress depends on a supportive and symbiotic relationship with those in the WordPress community.”

After establishing what the community is, how it was founded and the role of Mullenweg and Automattic as a strongly supportive of the community, it then paints a picture of WP Engine as a company that reaps huge benefits from the volunteer work and donated time without adequately giving back to the community. This is the part that Mullenweg and Automattic feel is left out of WP Engine’s complaint, that Mullenweg was expressing his opinion that not only should WP Engine should provide more support to the community and that Mullenweg was responding to the threat posed by the plaintiff’s behavior.

The motion explains:

“Plaintiff WP Engine’s conduct poses a threat to that community. WP Engine is a website hosting service built on the back of WordPress software and controlled by the private equity firm Silver Lake, which claims over $100B of assets under management.

…In addition to WordPress software, WP Engine also uses various of the free resources on the Website, and its Complaint alleges that access to the Website is now, apparently, critical for its business.”

Lastly, the beginning part of the motion, which explains the defendant’s side of the dispute, asserts that the defendant’s behavior was entirely within their legal right because no agreement exists between WordPress and WP Engine that guarantees them access to WordPress resources and that WP Engine at no time tried to secure rights to access.

The document continues:

“But the Complaint does not (and cannot) allege that WP Engine has any agreement with Matt (or anyone else for that matter) that gives WP Engine the right to use the Website’s resources. The Complaint does not (and cannot) allege that WP Engine at any time has attempted to secure that right from Matt or elsewhere.

Instead, WP Engine has exploited the free resources provided by the Website to make hundreds of millions of dollars annually. WP Engine has done so while refusing to meaningfully give back to the WordPress community, and while unfairly trading off the goodwill associated with the WordPress and WooCommerce trademarks.”

Accusation Of Trademark Infringement

The motion to dismiss filed by Mullenweg and Automattic accuse WP Engine of trademark infringement, a claim that has been at the heart of of Mullenweg’s dispute, which the legal response says is a dispute that Mullenweg attempted to amicably resolve in private.

The legal document asserts:

“In 2021, for the first time, WP Engine incorporated the WordPress trademark into the name of its own product offering which it called “Headless WordPress,” infringing that trademark and violating the express terms of the WordPress Foundation Trademark Policy, which prohibits the use of the WordPress trademarks in product names. And, over time, WP Engine has progressively increased its use and prominence of the WordPress trademark throughout its marketing materials, ultimately using that mark well beyond the recognized limits of nominative fair use.”

What Triggered The Dispute

The defendants claim that WP Engine benefited from the open source community but declined to become an active partner in the open source community. The defendants claim that they tried to bring WP Engine into the community as part of the symbiotic relationship but WP Engine refused.

The motion to dismiss is interesting because it first argues that WP Engine didn’t have an agreement with Automattic for use of the WordPress trademark nor did it had an agreement for the rights to have access to WordPress resources. Then it shows how the defendants tried to reach an agreement and that it was WP Engine’s refusal to “meaningfully give back to the WordPress community” and come to an agreement with Automattic is what triggered the dispute.

The document explains:

“Matt has attempted to raise these concerns with WP Engine and to reach an amicable resolution for the good of the community. In private, Matt also has encouraged WP Engine to give back to the ecosystem from which it has taken so much. Preserving and maintaining the resources made available on the Website requires considerable effort and investment—an effort and investment that Matt makes to benefit those with a shared sense of mission. WP Engine does not
embrace that mission.

WP Engine and Silver Lake cannot expect to profit off the back of others without carrying some of the weight—and that is all Matt has asked of them. For example, Matt suggested that WP Engine either execute a license for the Foundation’s WordPress trademarks or dedicate eight percent of its revenue to the further development of the open source WordPress software.”

Mullenweg Had Two Choices

The above is what Mullenweg and Automattic claim is at the heart of the dispute, the unwillingness of WP Engine to reach an agreement with Automattic and become a stronger partner with the community. The motion to dismiss say that WP Engine’s refusal to reach an agreement left Mullenweg few choices of what to do next, as the motion explains:.

“When it became abundantly clear to Matt that WP Engine had no interest in giving back, Matt was left with two choices: (i) continue to allow WP Engine to unfairly exploit the free resources of the Website, use the WordPress and WooCommerce trademarks without authorization, which would also threaten the very existence of those trademarks, and remain silent on the negative impact of its behavior or (ii) refuse to allow WP Engine to do that and demand publicly that WP Engine do more to support the community.”

Disputes Look Different From Each Side

Matt Mullenweg and Automattic have been portrayed in an unflattering light since the dispute with WP Engine burst into public. The motion to dismiss communicates that Mullenweg’s motivations were in defense of the WordPress community, proving that every dispute looks different depending on who is telling the story. Now it’s up to the judge to decide.

Featured Image by Shutterstock/santypan

The surprising barrier that keeps us from building the housing we need

Ahead of abortion access, ahead of immigration, and way ahead of climate change, US voters under 30 are most concerned about one issue: housing affordability. And it’s not just young voters who are identifying soaring rents and eye-watering home sale prices as among their top worries. For the first time in recent memory, the cost of housing could be a major factor in the presidential election.  

It’s not hard to see why. From the beginning of the pandemic to early 2024, US home prices rose by 47%. In large swaths of the country, buying a home is no longer a possibility even for those with middle-class incomes. For many, that marks the end of an American dream built around owning a house. Over the same time, rents have gone up 26%.

Vice President Kamala Harris has offered an ambitious plan to build more: “Right now, a serious housing shortage is part of what is driving up cost,” she said last month in Las Vegas. “So we will cut the red tape and work with the private sector to build 3 million new homes.” Included in her proposals is a $40 billion innovation fund to support housing construction.

Former president Donald Trump, meanwhile, has also called for cutting regulations but mostly emphasizes a far different way to tackle the housing crunch: mass deportation of the immigrants he says are flooding the country, and whose need for housing he claims is responsible for the huge jump in prices. (While a few studies show some local impact on the cost of housing from immigration in general, the effect is relatively small, and there is no plausible economic scenario in which the number of immigrants over the last few years accounts for the magnitude of the increase in home prices and rents across much of the country.)

The opposing views offered by Trump and Harris have implications not only for how we try to lower home prices but for how we view the importance of building. Moreover, this attention on the housing crisis also reveals a broader issue with the construction industry at large: This sector has been tech-averse for decades, and it has become less productive over the past 50 years.

The reason for the current rise in the cost of housing is clear to most economists: a lack of supply. Simply put, we don’t build enough houses and apartments, and we haven’t for years. Depending on how you count it, the US has a shortage of around 1.2 million to more than 5.5 million single-family houses.

Permitting delays and strict zoning rules create huge obstacles to building more and faster—as do other widely recognized issues, like the political power of NIMBY activists across the country and an ongoing shortage of skilled workers. But there is also another, less talked-about problem that’s plaguing the industry: We’re not very efficient at building, and we seem somehow to be getting worse.

Together these forces have made it more expensive to build houses, leading to increases in prices. Albert Saiz, a professor of urban economics and real estate at MIT, calculates that construction costs account for more than two-thirds of the price of a new house in much of the country, including the Southwest and West, where much of the building is happening. Even in places like California and New England, where land is extremely expensive, construction accounts for 40% to 60% of value of a new home, according to Saiz.

Part of the problem, Saiz says, is that “if you go to any construction site, you’ll see the same methods used 30 years ago.”

The productivity woes are evident across the construction industry, not just in the housing sector. From clean-energy advocates dreaming of renewables and an expanded power grid to tech companies racing to add data centers, everyone seems to agree: We need to build more and do it quickly. The practical reality, though, is that it costs more, and takes more time, to construct anything.

For decades, companies across the industry have largely ignored ways they could improve the efficiency of their operations. They have shunned data science and the kinds of automation that have transformed the other sectors of the economy. According to an estimation by the McKinsey Global Institute, construction, one of the largest parts of the global economy, is the least digitized major sector worldwide—and it isn’t even close.

The reality is that even if we ease the endless permitting delays and begin cutting red tape, we will still be faced with a distressing fact: The construction industry is not very efficient when it comes to building stuff.

The awful truth

Productivity is our best measure of long-term progress in an industry, at least according to economists. Technically, it’s a measure of how much a worker can produce; as companies adopt more efficient practices and new technologies, productivity grows and businesses can make stuff (in this case, homes and buildings) faster and more cheaply. Yet something shocking has happened in the construction industry: Productivity seems to have stalled and even gone into reverse over the last few decades.

In a recent paper called “The Strange and Awful Path of Productivity in the US Construction Sector,” two leading economists at the University of Chicago showed that productivity growth in US construction came to a halt beginning around 1970. Productivity is notoriously difficult to quantify, but the Chicago researchers calculated it in one of the key parts of the construction business: housing. They found that the number of houses or total square footage (houses are getting bigger) built per employee each year was flat or even falling over the last 50 years. And the researchers believe the lack of productivity growth holds true for all different types of construction.

Chad Syverson, one of the authors, admits he is still trying to pinpoint the reason—“It’s probably a few things.” While he says it’s difficult to quantify the specific impact of various factors on productivity, including the effects of regulatory red tape and political fights that often delay construction, “part of the industry’s problem is its own operational inefficiency,” he says. “There’s no doubt about it.” In other words, the industry just isn’t very innovative.

The lack of productivity in construction over the last half-century, at a time when all other sectors grew dramatically, is “really amazing,” he says—and not in a good way.

US manufacturing, in contrast, continued growing at around 2% to 3% annually over the same period. Auto workers, as a result, now produce far more cars than they once did, leading to cheaper vehicles if you adjust for inflation (and, by most measures, safer and better ones).

Productivity in construction is not just a US problem, according to the McKinsey Global Institute, which has tracked the issue for nearly a decade. Not all countries are faring as badly as the US, but worldwide construction productivity has been flat over the last few decades, says Jan Mischke, who heads the McKinsey work.

Beyond adding to the costs and threatening the financial viability of many planned projects, Mischke says, the lack of productivity is “reflected in all the mess, time and cost overruns, concerns about quality, rework, and all the things that everyone who has ever built anything will have seen.” 

The nature of construction work can make it difficult to improve longstanding processes and introduce new technologies, he says: “Most other sectors become better over time by doing the same thing twice or three times or 3 million times. They learn and improve. All that is essentially missing in construction, where every single project starts from scratch and reinvents the wheel.”

Mischke also sees another reason for the industry’s lack of productivity: the “misaligned incentives” of the various players, who often make more money the longer a project takes.

Though the challenges are endemic to the business, Mischke adds that builders can take steps to overcome them by moving to digital technologies, implementing more standardized processes, and improving the efficiency of their business practices.

“Most other sectors become better over time by doing the same thing twice or three times or 3 million times. All that is essentially missing in construction.”

It’s an urgent problem to solve as many countries race to build housing, expand clean-energy capabilities, and update infrastructure like roads and airports. In their latest report, the McKinsey researchers warn of the dangers if productivity doesn’t improve: “The net-zero transition may be delayed, growth ambitions may be deferred, and countries may struggle to meet the infrastructure and housing needs for their populations.”

But the report also says there’s a flip side to the lack of progress in much of the industry: Individual companies that begin to improve their efficiency could gain a huge competitive advantage.

Building on the data

When Jit Kee Chin joined Suffolk Construction as its chief data officer in 2017, the title was unique in the industry. But Chin, armed with a PhD in experimental physics from MIT and a 10-year stint at McKinsey, brought to the large Boston-based firm the kind of technical and management expertise often missing from construction companies. And she recognized that large construction projects—including the high-rise apartment buildings and sprawling data centers that Suffolk often builds—generate vast amounts of useful data.

At the time, much of the data was siloed; information on the progress of a project was in one place, scheduling in another, and safety data and reports in yet another. “The systems didn’t talk to each other, and it was very difficult to cross-correlate,” says Chin. Getting all the data together so it could be understood and utilized across the business was an early task.

“Almost all construction companies are talking about how to better use their data now,” says Chin, who is currently Suffolk’s CTO, and since her hiring, “a couple others have even appointed chief data officers.” But despite such encouraging signs, she sees the effort to improve productivity in the industry as still very much a work in progress.  

One ongoing and obvious target: the numerous documents that are constantly being revised as they move along from architect to engineers to subcontractors. It’s the lifeblood of any construction project, and Chin says the process “is by no means seamless.” Architects and subcontractors sometimes use different software; meanwhile, the legally binding documents spelling out details of a project are still circulated as printouts. A more frictionless flow of information among the multitude of players is critical to better coordinate the complex building process.

Ultimately, though, building is a physical activity. And while automation has largely been absent from building trades, robots are finally cheap enough to be attractive to builders, especially companies facing a shortage of workers. “The cost of off-the-shelf robotic components has come down to a point where it is feasible to think of simple robots automating a very repetitive task,” says Chin. And advances in robotic image recognition, lidar, AI, and dexterity, she says, mean robots are starting to be able to safely navigate construction sites.

One step in construction where digital designs meet the physical world is the process of laying out blueprints for walls and other structures on the floor of a building. It’s an exacting, time-consuming manual practice, prone to errors.

The Dusty Robotics field printer marks the layout for walls and other structures.
DUSTY ROBOTICS

And startups like Dusty Robotics are betting it’s an almost perfect application for a Roomba-like robot. Tessa Lau, its CEO, recalls that when she researched the industry before founding the company in 2018, she was struck by seeing “people on their hands and knees snapping chalk lines.”

Based in Silicon Valley, the company builds a box-shaped machine that scoots about a site on sturdy wheels to mark the layout. Though the company often markets it as a field printer to allay any fears about automation, it’s an AI-powered robot with advanced sensors that plan and guide its travels.

Not only does the robot automate a critical job, but because that task is so central in the construction process, it also helps open a digital window into the overall workflow of a project.

A history lesson

Whatever the outcome of the upcoming election, don’t hold your breath waiting for home prices to fall; even if we do build more (or somehow decrease demand), it will probably take years for the supply to catch up. But the political spotlight on housing affordability could be a rare opportunity to focus on the broad problem of construction productivity.  

While some critics have argued that Harris’s plan is too vague and lacks the ambition required to solve the housing crisis, her message that we need to build more and faster is the right one. “It takes too long and it costs too much to build. Whether it’s a new housing development, a new factory, or a new bridge, projects take too long to go from concept to reality,” Harris said in a speech in late September. Then she asked: “You know long it took to build [the Empire State Building]?”

Harris stresses cutting red tape to unleash a building boom. That’s critical, but it’s only part of the long-term answer. The construction of the famous New York City skyscraper took just over a year in 1931—a feat that provides valuable clues to how the industry itself can finally increase its productivity.

The explanation for why it was built so quickly has less to do with new technologies—in fact, the engineers mostly opted for processes and materials that were familiar and well-tested at the time—and more to do with how the project leaders managed every aspect of the design and construction process for speed and efficiency. The activity of the thousands of workers was carefully scheduled and tracked, and the workflow was highly choreographed to minimize delays. Even the look of the 1,250-foot building was largely a result of choosing the fastest and simplest way to build.

To a construction executive like Suffolk’s Chin, who estimates it would take at least four years to construct such a building today, the lessons of the Empire State Building resonate, especially the operational discipline and the urgency to finish the structure as quickly as possible. “It’s a stark difference when you think about how much time it took and how much time it would take to build that building now,” she says.

If we want an affordable future, the construction business needs to recapture that sense of urgency and efficiency. To do so, the industry will need to change the way it operates and alter its incentive structures; it will need to incorporate the right mix of automation and find financial models that will transform outdated business practices. The good news is that advances in data science, automation, and AI are offering companies new opportunities to do just that.

The hope, then, is that capitalism will do capitalism. Innovative firms will (hopefully) build more cheaply and faster, boost their profits, and become more competitive. Such companies will prosper, and others will begin to mimic the early adopters, investing in the new technologies and business models. In other words, the reality of seeing some builders profit by using data and automation will finally help drag the construction industry into the modern digital age.

Inside a fusion energy facility

This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here.

On an overcast day in early October, I picked up a rental car and drove to Devens, Massachusetts, to visit a hole in the ground.

Commonwealth Fusion Systems has raised over $2 billion in funding since it spun out of MIT in 2018, all in service of building the first commercial fusion reactor. The company has ambitions to build power plants, but currently the goal is to finish putting together its first demonstration system, the SPARC reactor. The plan is to have it operating by 2026.

I visited the company’s site recently to check in on progress. Things are starting to come together around the hole in the floor where SPARC will eventually be installed. Looking around the site, I found it becoming easier to imagine a future that could actually include fusion energy. But there’s still a lot of work left to do. 

Fusion power has been a dream for decades. The idea is simple: Slam atoms together and use the energy that’s released to power the world. The systems would require small amounts of abundant fuel and wouldn’t produce dangerous waste. The problem is, executing this vision has been much slower than many had hoped.

Commonwealth is one of the leaders in commercial fusion. My colleague James Temple wrote a feature story, published in early 2022, about the company’s attempts to bring the technology to reality. At the time, the Devens location was still a muddy construction site, with the steel and concrete just starting to go into the ground.

Things are much more polished now—when I visited earlier this month, I pulled into one of the designated visitor parking spots and checked in at a reception desk in a bustling office building before beginning my tour. There were two main things to see: the working magnet factory and the cluster of buildings that will house and support the SPARC reactor.

We started in the magnet factory. SPARC is a tokamak, a device relying on powerful magnets to contain the plasma where fusion reactions take place. There will be three different types of magnets in SPARC, all arranged to keep the plasma in position and moving around in the right way.

The company is making its own magnets powered with tape made from a high-temperature superconductor, which generates a magnetic field when an electric current runs through it. SPARC will contain thousands of miles’ worth of this tape in its magnets. In the factory, specialized equipment winds up the tape and tucks it into metal cases, which are then stacked together and welded into protective shells.  

After our quick loop around the magnet factory, I donned a helmet, neon vest, and safety glasses and got a short safety talk that included a stern warning to not stare directly at any welding. Then we walked across a patio and down a gravel driveway to the main complex of buildings that will house the SPARC reactor.

Except for some remaining plywood stairs and dust, the complex appeared to be nearly completed. There’s a huge wall of glass on the front of the building—a feature intended to show that the company is open with the community about the goings-on inside, as my tour guide, chief marketing officer Joe Paluska, put it.  

Four main buildings surround the central tokamak hall. These house support equipment needed to cool down the magnets, heat up the plasma, and measure conditions in the reactor. Most of these big, industrial systems that support SPARC are close to being ready to turn on or are actively being installed, explained Alex Creely, director of tokamak operations, in a call after my tour.

When it was finally time to see the tokamak hall that will house SPARC, we had to take a winding route to get there. A maze of concrete walls funneled us to the entrance, and I lost track of my left and right turns. Called the labyrinth, this is a safety feature, designed to keep stray neutrons from escaping the hall once the reactor is operating. (Neutrons are a form of radiation, and enough exposure can be dangerous to humans.) 

Finally, we stepped into a cavernous space. From our elevated vantage point on a metal walkway, we peered down into a room with gleaming white floors and equipment scattered around the perimeter. At the center was a hole, covered with a tarp and surrounded by bright-yellow railings. That empty slot is where the star of the show, SPARC, will eventually be installed.

tokamak hall at Commonwealth Fusion Systems
The tokamak hall at Commonwealth Fusion Systems will house the company’s SPARC reactor.
COMMONWEALTH FUSION SYSTEMS

While there’s still very little tokamak in the tokamak hall right now, Commonwealth has an ambitious timeline planned: The goal is to have SPARC running and the first plasma in the reactor by 2026. The company plans to demonstrate that it can produce more energy in the reactor than is needed to power it (a milestone known as Q>1 in the fusion world) by 2027.

When we published our 2022 story on Commonwealth, the plan was to flip on the reactor and reach the Q>1 milestone by 2025, so the timeline has slipped. It’s not uncommon for big projects in virtually every industry to take longer than expected. But there’s an especially long and fraught history of promises and missed milestones in fusion. 

Commonwealth has certainly made progress over the past few years, and it’s getting easier to imagine the company actually turning on a reactor and meeting the milestones the field has been working toward for decades. But there’s still a tokamak-shaped hole in suburban Massachusetts waiting to be filled. 


Now read the rest of The Spark

Related reading

Read our 2022 feature on Commonwealth Fusion Systems and its path to commercializing fusion energy here

In late 2022, a reactor at a national lab in the US generated more energy than was put in, a first for the industry. Here’s what meeting that milestone actually means for clean energy

There’s still a lot of research to be done in fusion—here’s what’s coming next

Another company called Helion says its first fusion power plant is five years away. Experts are skeptical, to say the least.

AI e-waste

PHOTO ILLUSTRATION BY SARAH ROGERS/MITTR | PHOTOS GETTY

Another thing

Generative AI will add to our growing e-waste problem. A new study estimates that AI could add up to 5 million tons of e-waste by 2030. 

It’s a small fraction of the total, but there’s still good reason to think carefully about how we handle discarded servers and high-performance computing equipment, according to experts. Read more in my latest story

Keeping up with climate  

New York City will buy 10,000 induction stoves from a startup called Copper. The stoves will be installed in public housing in the city. (Heatmap)

Demand is growing for electric cabs in India, but experts say there’s not nearly enough supply to meet it. (Rest of World)

Pivot Bio aims to tweak the DNA of bacteria so they can help deliver nutrients to plants. The company is trying to break into an industry dominated by massive agriculture and chemical companies. (New York Times)

→ Check out our profile of Pivot Bio, which was one of our 15 Climate Tech Companies to Watch this year. (MIT Technology Review)

At least 62 people are dead and many more are missing in dangerous flooding across Spain. (Washington Post

A massive offshore wind lease sale this week offered up eight patches of ocean off the coast of Maine in the US. Four sold, opening the door for up to 6.8 gigawatts of additional offshore wind power. (Canary Media)

Climate change contributed to the deaths of 38,000 people across Europe in the summer of 2022, according to a new study. (The Guardian)

→ The legacy of Europe’s heat waves will be more air-conditioning, and that could be its own problem. (MIT Technology Review)

There are nearly 9,000 public fast-charging sites in the US, and a surprising wave of installations in the Midwest and Southeast. (Bloomberg)

Some proposed legislation aims to ban factory farming, but determining what that category includes is way more complicated than you might think. (Ambrook Research)

The Download: US house-building barriers, and a fusion energy facility tour

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Housing is an election issue. But the US sucks at it.

Ahead of abortion access, ahead of immigration, and way ahead of climate change, US voters under 30 are most concerned about one issue: housing affordability. And it’s not just young voters who say soaring rents and eye-watering home sale prices are among their top worries. For the first time in recent memory, the cost of housing could be a major factor in the presidential election.  

It’s not hard to see why. From the beginning of the pandemic to early 2024, US home prices rose by 47%. In large swaths of the country, buying a home is no longer a possibility even for those with middle-class incomes. 

Permitting delays and strict zoning rules create huge obstacles to building more and faster—as do other widely recognized issues, like the political power of NIMBY activists across the country and an ongoing shortage of skilled workers. But there is also another, less talked-about problem: We’re not very efficient at building, and we seem somehow to be getting worse. Read the full story.

—David Rotman

Inside a fusion energy facility

—Casey Crownhart

On an overcast day in early October, I picked up a rental car and drove to Devens, Massachusetts, to visit a hole in the ground.

Commonwealth Fusion Systems has raised over $2 billion in funding since it spun out of MIT in 2018, all in service of building the first commercial fusion reactor. The plan is to have it operating by 2026.

I visited the company’s site recently to check in on progress. Things are starting to come together and, looking around the site, I found it becoming easier to imagine a future that could actually include fusion energy. But there’s still a lot of work left to do. Read the full story.

This story is from The Spark, our weekly climate and energy newsletter. Sign up to receive it in your inbox every Wednesday.

MIT Technology Review Narrated: How gamification took over the world

Instead of liberating us from drudgery and maximizing our potential, gamification has turned out to be just another tool for coercion, distraction, and control. Why did we fall for it?

This is our latest story to be turned into a MIT Technology Review Narrated podcast. In partnership with News Over Audio, we’ll be making a selection of our stories available, each one read by a professional voice actor. You’ll be able to listen to them on the go or download them to listen to offline.

We’re publishing a new story each week on Spotify and Apple Podcasts, including some taken from our most recent print magazine.

Just navigate to MIT Technology Review Narrated on either platform, and follow us to get all our new content as it’s released.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Bird flu has been found in a pig in the US for the first time 
The USDA says it’s not cause for panic. But it’s certainly cause for concern. (Reuters)
Why virologists are getting increasingly nervous about bird flu. (MIT Technology Review)
 
2 Elon Musk has turned X into a political weapon 
This is what $44 billion bought him: the ability to flood the zone with falsehoods during an election. (The Atlantic $)
X’s crowdsourced fact-checking program is falling woefully short. (WP $)
And it’s not just X. YouTube is full of election conspiracy content too. (NYT $)
+ Spare a thought for the election officials who have to navigate this mess. (NPR)
 
3 Europe’s big tech hawks are nervously eyeing the US election
Biden was an ally in their efforts to crack down. Either of his potential successors look like a less sure bet. (Wired $)
Attendees regularly fail to disclose their links to big tech at EU events. (The Guardian)
 
4 The AI boom is being powered by concrete
It’s a major ingredient for data centers and the power plants being built to serve them—and a climate disaster. (IEEE Spectrum)
How electricity could help tackle a surprising climate villain. (MIT Technology Review)
 
5 What makes human brains so special? 🧠
Much of the answer is still a mystery—but researchers are uncovering more and more promising leads. (Nature)
+ Tech that measures our brainwaves is 100 years old. How will we be using it 100 years from now? (MIT Technology Review)
 
6 Boston Dynamics’ humanoid robot is getting much more capable
If its latest video, in which it autonomously picks up and moves car parts, is anything to go by. (TechCrunch)
A skeptic’s guide to humanoid-robot videos. (MIT Technology Review)
 
7 Alexa desperately needs a revamp
The voice assistant was launched 10 years ago, and it’s been disappointing us ever since. (The Verge
 
8 We’re sick of algorithms recommending us stuff
Lots of people are keen to turn back to guidance from other humans. (New Yorker $)
If you’re one of them, I have bad news: AI is going to make the problem much worse. (Fortune $)
 
9 Russia fined Google $20,000,000,000,000,000,000,000,000,000,000,000
That’s more money than exists on Earth but sure, don’t let that stop you. (The Register)
 
10 What is going on with Mark Zuckerberg recently 
He’s using clothes to rebrand himself and… it’s kinda working?! (Slate)

Quote of the day

“It’s what happens when you let a bunch of grifters take over.”

—A Trumpworld source explains to Wired why Donald Trump’s ground campaign in Michigan is so chaotic. 

 The big story

A day in the life of a Chinese robotaxi driver

worldcoin orb

WORLDCOIN

July 2022

When Liu Yang started his current job, he found it hard to go back to driving his own car: “I instinctively went for the passenger seat. Or when I was driving, I would expect the car to brake by itself,” says the 33-year-old Beijing native, who joined the Chinese tech giant Baidu in January 2021 as a robotaxi driver.

Liu is one of the hundreds of safety operators employed by Baidu, “driving” five days a week in Shougang Park. But despite having only worked for the company for 19 months, he already has to think about his next career move, as his job will likely be eliminated within a few years. Read the full story.

—Zeyi Yang

We can still have nice things

A place for comfort, fun and distraction to brighten up your day. (Got any ideas? Drop me a line or tweet ’em at me.)

+ Happy Halloween! Check out some of the best spine-chilling classic novels
+ If scary movies are more your jam, I’ve still got you covered.
+ These photo montages of music fans outside concerts are incredible. 
+ Love that this guy went from being terrified of rollercoasters to designing them.
+ You’ll probably never sort your life out. And that’s OK.

Chasing AI’s value in life sciences

Inspired by an unprecedented opportunity, the life sciences sector has gone all in on AI. For example, in 2023, Pfizer introduced an internal generative AI platform expected to deliver $750 million to $1 billion in value. And Moderna partnered with OpenAI in April 2024, scaling its AI efforts to deploy ChatGPT Enterprise, embedding the tool’s capabilities across business functions from legal to research.

In drug development, German pharmaceutical company Merck KGaA has partnered with several AI companies for drug discovery and development. And Exscientia, a pioneer in using AI in drug discovery, is taking more steps toward integrating generative AI drug design with robotic lab automation in collaboration with Amazon Web Services (AWS).

Given rising competition, higher customer expectations, and growing regulatory challenges, these investments are crucial. But to maximize their value, leaders must carefully consider how to balance the key factors of scope, scale, speed, and human-AI collaboration.

The early promise of connecting data

The common refrain from data leaders across all industries—but specifically from those within data-rich life sciences organizations—is “I have vast amounts of data all over my organization, but the people who need it can’t find it.” says Dan Sheeran, general manager of health care and life sciences for AWS. And in a complex healthcare ecosystem, data can come from multiple sources including hospitals, pharmacies, insurers, and patients.

“Addressing this challenge,” says Sheeran, “means applying metadata to all existing data and then creating tools to find it, mimicking the ease of a search engine. Until generative AI came along, though, creating that metadata was extremely time consuming.”

ZS’s global head of the digital and technology practice, Mahmood Majeed notes that his teams regularly work on connected data programs, because “connecting data to enable connected decisions across the enterprise gives you the ability to create differentiated experiences.”

Majeed points to Sanofi’s well-publicized example of connecting data with its analytics app, plai, which streamlines research and automates time-consuming data tasks. With this investment, Sanofi reports reducing research processes from weeks to hours and the potential to improve target identification in therapeutic areas like immunology, oncology, or neurology by 20% to 30%.

Achieving the payoff of personalization

Connected data also allows companies to focus on personalized last-mile experiences. This involves tailoring interactions with healthcare providers and understanding patients’ individual motivations, needs, and behaviors.

Early efforts around personalization have relied on “next best action” or “next best engagement” models to do this. These traditional machine learning (ML) models suggest the most appropriate information for field teams to share with healthcare providers, based on predetermined guidelines.

When compared with generative AI models, more traditional machine learning models can be inflexible, unable to adapt to individual provider needs, and they often struggle to connect with other data sources that could provide meaningful context. Therefore, the insights can be helpful but limited.  

Sheeran notes that companies have a real opportunity to improve their ability to gain access to connected data for better decision-making processes, “Because the technology is generative, it can create context based on signals. How does this healthcare provider like to receive information? What insights can we draw about the questions they’re asking? Can their professional history or past prescribing behavior help us provide a more contextualized answer? This is exactly what generative AI is great for.”

Beyond this, pharmaceutical companies spend millions of dollars annually to customize marketing materials. They must ensure the content is translated, tailored to the audience and consistent with regulations for each location they offer products and services. A process that usually takes weeks to develop individual assets has become a perfect use case for generative copy and imagery. With generative AI, the process is reduced to from weeks to minutes and creates competitive advantage with lower costs per asset, Sheeran says.

Accelerating drug discovery with AI, one step at a time

Perhaps the greatest hope for AI in life sciences is its ability to generate insights and intellectual property using biology-specific foundation models. Sheeran says, “our customers have seen the potential for very, very large models to greatly accelerate certain discrete steps in the drug discovery and development processes.” He continues, “Now we have a much broader range of models available, and an even larger set of models coming that tackle other discrete steps.”

By Sheeran’s count, there are approximately six major categories of biology-specific models, each containing five to 25 models under development or already available from universities and commercial organizations.

The intellectual property generated by biology-specific models is a significant consideration, supported by services such as Amazon Bedrock, which ensures customers retain control over their data, with transparency and safeguards to prevent unauthorized retention and misuse.

Finding differentiation in life sciences with scope, scale, and speed

Organizations can differentiate with scope, scale, and speed, while determining how AI can best augment human ingenuity and judgment. “Technology has become so easy to access. It’s omnipresent. What that means is that it’s no longer a differentiator on its own,” says Majeed. He suggests that life sciences leaders consider:

Scope: Have we zeroed in on the right problem? By clearly articulating the problem relative to the few critical things that could drive advantage, organizations can identify technology and business collaborators and set standards for measuring success and driving tangible results.

Scale: What happens when we implement a technology solution on a large scale? The highest-priority AI solutions should be the ones with the most potential for results.Scale determines whether an AI initiative will have a broader, more widespread impact on a business, which provides the window for a greater return on investment, says Majeed.

By thinking through the implications of scale from the beginning, organizations can be clear on the magnitude of change they expect and how bold they need to be to achieve it. The boldest commitment to scale is when companies go all in on AI, as Sanofi is doing, setting goals to transform the entire value chain and setting the tone from the very top.

Speed: Are we set up to quickly learn and correct course? Organizations that can rapidly learn from their data and AI experiments, adjust based on those learnings, and continuously iterate are the ones that will see the most success. Majeed emphasizes, “Don’t underestimate this component; it’s where most of the work happens. A good partner will set you up for quick wins, keeping your teams learning and maintaining momentum.”

Sheeran adds, “ZS has become a trusted partner for AWS because our customers trust that they have the right domain expertise. A company like ZS has the ability to focus on the right uses of AI because they’re in the field and on the ground with medical professionals giving them the ability to constantly stay ahead of the curve by exploring the best ways to improve their current workflows.”

Human-AI collaboration at the heart

Despite the allure of generative AI, the human element is the ultimate determinant of how it’s used. In certain cases, traditional technologies outperform it, with less risk, so understanding what it’s good for is key. By cultivating broad technology and AI fluency throughout the organization, leaders can teach their people to find the most powerful combinations of human-AI collaboration for technology solutions that work. After all, as Majeed says, “it’s all about people—whether it’s customers, patients, or our own employees’ and users’ experiences.”

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

OpenAI brings a new web search tool to ChatGPT

ChatGPT can now search the web for up-to-date answers to a user’s queries, OpenAI announced today. 

Until now, ChatGPT was mostly restricted to generating answers from its training data, which is current up to October 2023 for GPT-4o, and had limited web search capabilities. Searches about generalized topics will still draw on this information from the model itself, but now ChatGPT will automatically search the web in response to queries about recent information such as sports, stocks, or news of the day, and can deliver rich multi-media results. Users can also manually trigger a web search, but for the most part, the chatbot will make its own decision about when an answer would benefit from information taken from the web, says Adam Fry, OpenAI’s product lead for search.

“Our goal is to make ChatGPT the smartest assistant, and now we’re really enhancing its capabilities in terms of what it has access to from the web,” Fry tells MIT Technology Review. The feature is available today for the chatbot’s paying users. 

ChatGPT triggers a web search when the user asks about local restaurants in this example

While ChatGPT search, as it is known, is initially available to paying customers, OpenAI intends to make it available for free later, even when people are logged out. The company also plans to combine search with its voice features and Canvas, its interactive platform for coding and writing, although these capabilities will not be available in today’s initial launch.

The company unveiled a standalone prototype of web search in July. Those capabilities are now built directly into the chatbot. OpenAI says it has “brought the best of the SearchGPT experience into ChatGPT.” 

OpenAI is the latest tech company to debut an AI-powered search assistant, challenging similar tools from competitors such as Google, Microsoft, and startup Perplexity. Meta, too, is reportedly developing its own AI search engine. As with Perplexity’s interface, users of ChatGPT search can interact with the chatbot in natural language, and it will offer an AI-generated answer with sources and links to further reading. In contrast, Google’s AI Overviews offer a short AI-generated summary at the top of the website, as well as a traditional list of indexed links. 

These new tools could eventually challenge Google’s 90% market share in online search. AI search is a very important way to draw more users, says Chirag Shah, a professor at the University of Washington, who specializes in online search. But he says it is unlikely to chip away at Google’s search dominance. Microsoft’s high-profile attempt with Bing barely made a dent in the market, Shah says. 

Instead, OpenAI is trying to create a new market for more powerful and interactive AI agents, which can take complex actions in the real world, Shah says. 

The new search function in ChatGPT is a step toward these agents. 

It can also deliver highly contextualized responses that take advantage of chat histories, allowing users to go deeper in a search. Currently, ChatGPT search is able to recall conversation histories and continue the conversation with questions on the same topic. 

ChatGPT itself can also remember things about users that it can use later —sometimes it does this automatically, or you can ask it to remember something. Those “long-term” memories affect how it responds to chats. Search doesn’t have this yet—a new web search starts from scratch— but it should get this capability in the “next couple of quarters,” says Fry. When it does, OpenAI says it will allow it to deliver far more personalized results based on what it knows.

“Those might be persistent memories, like ‘I’m a vegetarian,’ or it might be contextual, like ‘I’m going to New York in the next few days,’” says Fry. “If you say ‘I’m going to New York in four days,’ it can remember that fact and the nuance of that point,” he adds. 

To help develop ChatGPT’s web search, OpenAI says it leveraged its partnerships with news organizations such as Reuters, the Atlantic, Le Monde, the Financial Times, Axel Springer, Condé Nast, and Time. However, its results include information not only from these publishers, but any other source online that does not actively block its search crawler.   

It’s a positive development that ChatGPT will now be able to retrieve information from these reputable online sources and generate answers based on them, says Suzan Verberne, a professor of natural-language processing at Leiden University, who has studied information retrieval. It also allows users to ask follow-up questions.

But despite the enhanced ability to search the web and cross-check sources, the tool is not immune from the persistent tendency of AI language models to make things up or get it wrong. When MIT Technology Review tested the new search function and asked it for vacation destination ideas, ChatGPT suggested “luxury European destinations” such as Japan, Dubai, the Caribbean islands, Bali, the Seychelles, and Thailand. It offered as a source an article from the Times, a British newspaper, which listed these locations as well as those in Europe as luxury holiday options.

“Especially when you ask about untrue facts or events that never happened, the engine might still try to formulate a plausible response that is not necessarily correct,” says Verberne. There is also a risk that misinformation might seep into ChatGPT’s answers from the internet if the company has not filtered its sources well enough, she adds. 

Another risk is that the current push to access the web through AI search will disrupt the internet’s digital economy, argues Benjamin Brooks, a fellow at Harvard University’s Berkman Klein Center, who previously led public policy for Stability AI, in an op-ed published by MIT Technology Review today.

“By shielding the web behind an all-knowing chatbot, AI search could deprive creators of the visits and ‘eyeballs’ they need to survive,” Brooks writes.