How social media encourages the worst of AI boosterism

Demis Hassabis, CEO of Google DeepMind, summed it up in three words: “This is embarrassing.”  

Hassabis was replying on X to an overexcited post by Sébastien Bubeck, a research scientist at the rival firm OpenAI, announcing that two mathematicians had used OpenAI’s latest large language model, GPT-5, to find solutions to 10 unsolved problems in mathematics. “Science acceleration via AI has officially begun,” Bubeck crowed.

Put your math hats on for a minute, and let’s take a look at what this beef from mid-October was about. It’s a perfect example of what’s wrong with AI right now.

Bubeck was excited that GPT-5 seemed to have somehow solved a number of puzzles known as Erdős problems.

Paul Erdős, one of the most prolific mathematicians of the 20th century, left behind hundreds of puzzles when he died. To help keep track of which ones have been solved, Thomas Bloom, a mathematician at the University of Manchester, UK, set up erdosproblems.com, which lists more than 1,100 problems and notes that around 430 of them come with solutions. 

When Bubeck celebrated GPT-5’s breakthrough, Bloom was quick to call him out. “This is a dramatic misrepresentation,” he wrote on X. Bloom explained that a problem isn’t necessarily unsolved if this website does not list a solution. That simply means Bloom wasn’t aware of one. There are millions of mathematics papers out there, and nobody has read all of them. But GPT-5 probably has.

It turned out that instead of coming up with new solutions to 10 unsolved problems, GPT-5 had scoured the internet for 10 existing solutions that Bloom hadn’t seen before. Oops!

There are two takeaways here. One is that breathless claims about big breakthroughs shouldn’t be made via social media: Less knee jerk and more gut check.

The second is that GPT-5’s ability to find references to previous work that Bloom wasn’t aware of is also amazing. The hype overshadowed something that should have been pretty cool in itself.

Mathematicians are very interested in using LLMs to trawl through vast numbers of existing results, François Charton, a research scientist who studies the application of LLMs to mathematics at the AI startup Axiom Math, told me when I talked to him about this Erdős gotcha.

But literature search is dull compared with genuine discovery, especially to AI’s fervent boosters on social media. Bubeck’s blunder isn’t the only example.

In August, a pair of mathematicians showed that no LLM at the time was able to solve a math puzzle known as Yu Tsumura’s 554th Problem. Two months later, social media erupted with evidence that GPT-5 now could. “Lee Sedol moment is coming for many,” one observer commented, referring to the Go master who lost to DeepMind’s AI AlphaGo in 2016.

But Charton pointed out that solving Yu Tsumura’s 554th Problem isn’t a big deal to mathematicians. “It’s a question you would give an undergrad,” he said. “There is this tendency to overdo everything.”

Meanwhile, more sober assessments of what LLMs may or may not be good at are coming in. At the same time that mathematicians were fighting on the internet about GPT-5, two new studies came out that looked in depth at the use of LLMs in medicine and law (two fields that model makers have claimed their tech excels at). 

Researchers found that LLMs could make certain medical diagnoses, but they were flawed at recommending treatments. When it comes to law, researchers found that LLMs often give inconsistent and incorrect advice. “Evidence thus far spectacularly fails to meet the burden of proof,” the authors concluded.

But that’s not the kind of message that goes down well on X. “You’ve got that excitement because everybody is communicating like crazy—nobody wants to be left behind,” Charton said. X is where a lot of AI news drops first, it’s where new results are trumpeted, and it’s where key players like Sam Altman, Yann LeCun, and Gary Marcus slug it out in public. It’s hard to keep up—and harder to look away.

Bubeck’s post was only embarrassing because his mistake was caught. Not all errors are. Unless something changes researchers, investors, and non-specific boosters will keep teeing each other up. “Some of them are scientists, many are not, but they are all nerds,” Charton told me. “Huge claims work very well on these networks.”

*****

There’s a coda! I wrote everything you’ve just read above for the Algorithm column in the January/February 2026 issue of MIT Technology Review magazine (out very soon). Two days after that went to press, Axiom told me its own math model, AxiomProver, had solved two open Erdős problems (#124 and #481, for the math fans in the room). That’s impressive stuff for a small startup founded just a few months ago. Yup—AI moves fast!

But that’s not all. Five days later the company announced that AxiomProver had solved nine out of 12 problems in this year’s Putnam competition, a college-level math challenge that some people consider harder than the better-known International Math Olympiad (which LLMs from both Google DeepMind and OpenAI aced a few months back). 

The Putnam result was lauded on X by big names in the field, including Jeff Dean, chief scientist at Google DeepMind, and Thomas Wolf, cofounder at the AI firm Hugging Face. Once again familiar debates played out in the replies. A few researchers pointed out that while the International Math Olympiad demands more creative problem-solving, the Putnam competition tests math knowledge—which makes it notoriously hard for undergrads, but easier, in theory, for LLMs that have ingested the internet.

How should we judge Axiom’s achievements? Not on social media, at least. And the eye-catching competition wins are just a starting point. Determining just how good LLMs are at math will require a deeper dive into exactly what these models are doing when they solve hard (read: hard for humans) math problems.

This story originally appeared in The Algorithm, our weekly newsletter on AI. To get stories like this in your inbox first, sign up here.

How I learned to stop worrying and love AI slop

Lately, everywhere I scroll, I keep seeing the same fish-eyed CCTV view: a grainy wide shot from the corner of a living room, a driveway at night, an empty grocery store. Then something impossible happens. JD Vance shows up at the doorstep in a crazy outfit. A car folds into itself like paper and drives away. A cat comes in and starts hanging out with capybaras and bears, as if in some weird modern fairy tale.

This fake-surveillance look has become one of the signature flavors of what people now call AI slop. For those of us who spend time online watching short videos, slop feels inescapable: a flood of repetitive, often nonsensical AI-generated clips that washes across TikTok, Instagram, and beyond. For that, you can thank new tools like OpenAI’s Sora (which exploded in popularity after launching in app form in September), Google’s Veo series, and AI models built by Runway. Now anyone can make videos, with just a few taps on a screen. 

@absolutemem

If I were to locate the moment slop broke through into popular consciousness, I’d pick the video of rabbits bouncing on a trampoline that went viral this summer. For many savvy internet users, myself included, it was the first time we were fooled by an AI video, and it ended up spawning a wave of almost identical riffs, with people making videos of all kinds of animals and objects bouncing on the same trampoline. 

My first reaction was that, broadly speaking, all of this sucked. That’s become a familiar refrain, in think pieces and at dinner parties. Everything online is slop now—the internet “enshittified,” with AI taking much of the blame. Initially, I largely agreed, quickly scrolling past every AI video in a futile attempt to send a message to my algorithm. But then friends started sharing AI clips in group chats that were compellingly weird, or funny. Some even had a grain of brilliance buried in the nonsense. I had to admit I didn’t fully understand what I was rejecting—what I found so objectionable. 

To try to get to the bottom of how I felt (and why), I recently spoke to the people making the videos, a company creating bespoke tools for creators, and experts who study how new media becomes culture. What I found convinced me that maybe generative AI will not end up ruining everything. Maybe we have been too quick to dismiss AI slop. Maybe there’s a case for looking beyond the surface and seeing a new kind of creativity—one we’re watching take shape in real time, with many of us actually playing a part. 

 The slop boom

“AI slop” can and does refer to text, audio, or images. But what’s really broken through this year is the flood of quick AI-generated video clips on social platforms, each produced by a short written prompt fed into an AI model. Under the hood, these models are trained on enormous data sets so they can predict what every subsequent frame should look or sound like. It’s much like the process by which text models produce answers in a chat, but slower and far more power-hungry.

Early text-to-video systems, released around 2022 to 2023, could manage only a few seconds of blurry motion; objects warped in and out of existence, characters teleported around, and the giveaway that it was AI was usually a mangled hand or a melting face. In the past two years, newer models like Sora2, Veo 3.1, and Runway’s latest Gen-4.5 have dramatically improved, creating realistic, seamless, and increasingly true-to-prompt videos that can last up to a minute. Some of these models even generate sound and video together, including ambient noise and rough dialogue.

These text-to-video models have often been pitched by AI companies as the future of cinema—tools for filmmakers, studios, and professional storytellers. The demos have leaned into widescreen shots and dramatic camera moves. OpenAI pitched Sora as a “world simulator” while courting Hollywood filmmakers with what it boasted were movie-quality shorts. Google introduced Veo 3 last year as a step toward storyboards and longer scenes, edging directly into film workflows. 

All this hinged on the idea that people wanted to make AI-generated videos that looked real. But the reality of how they’re being used is more modest, weirder—and arguably much more interesting. What has turned out to be the home turf for AI video is the six-inch screen in our hands. 

Anyone can and does use these tools; a report by Adobe released in October shows that 86% of creators are using generative AI. But so are average social media users—people who aren’t “creators” so much as just people with phones. 

That’s how you end up with clips showing things like Indian prime minister Narendra Modi dancing with Gandhi, a crystal that melts into butter the moment a knife touches it, or Game of Thrones reimagined as Henan opera—videos that are hypnotic, occasionally funny, and often deeply stupid. And while micro-trends didn’t start with AI—TikTok and Reels already ran on fast-moving formats—it feels as if AI poured fuel on that fire. Perhaps because the barrier to copying an idea becomes so low, a viral video like the bunnies on trampoline can easily and quickly spawn endless variations on the same concept. You don’t need a costume or a filming location anymore; you just tweak the prompt, hit Generate, and share. 

Big tech companies have also jumped on the idea of AI videos as a new social medium. The Sora app allows users to insert AI versions of themselves and other users into scenes. Meta’s Vibes app wants to turn your entire feed into nonstop AI clips.

Of course, the same frictionless setup that allows for harmless, delightful creations also makes it easy to generate much darker slop. Sora has already been used to create so many racist deepfakes of Martin Luther King Jr. that the King estate pushed the company to block new MLK videos entirely. TikTok and X are seeing Sora-watermarked clips of women and girls being strangled circulating in bulk, posted by accounts seemingly dedicated to this one theme. And then there’s “nazislop,” the nickname for AI videos that repackage fascist aesthetics and memes into glossy, algorithm-ready content aimed at teens’ For You pages.

But the prevalence of bad actors hasn’t stopped short AI videos from flourishing as a form. New apps, Discord servers for AI creators, and tutorial channels keep multiplying. And increasingly, the energy in the community seems to be shifting away from trying to create stuff that “passes as real” toward embracing AI’s inherent weirdness. Every day, I stumble across creators who are stretching what “AI slop” is supposed to look like. I decided to talk to some of them.

Meet the creators

Like those fake surveillance videos, many popular viral AI videos rely on a surreal, otherworldly quality. As Wenhui Lim, an architecture designer turned full-time AI artist, tells me, “There is definitely a competition of ‘How weird we can push this?’ among AI video creators.”  

It’s the kind of thing AI video tools seem to handle with ease: pushing physics past what a normal body can do or a normal camera can capture. This makes AI a surprisingly natural fit for satire, comedy skits, parody, and experimental video art—especially examples involving absurdism or even horror. Several popular AI creators that I spoke with eagerly tap into this capability. 

Drake Garibay, a 39-year-old software developer from Redlands, California, was inspired by body-horror AI clips circulating on social media in early 2025. He started playing with ComfyUI, a generative media tool, and ended up spending hours each week making his own strange creations. His favorite subject is morbid human-animal hybrids. “I fell right into it,” he says. “I’ve always been pretty artistic, [but] when I saw what AI video tools can do, I was blown away.”

Since the start of this year, Garibay has been posting his experiments online. One that went viral on TikTok, captioned “Cooking up some fresh AI slop,” shows a group of people pouring gooey dough into a pot. The mixture suddenly sprouts a human face, which then emerges from the boiling pot with a head and body. It has racked up more than 8.3 million views.

@digitalpersons

AI video technology is evolving so quickly that even for creative professionals, there is a lot to experiment with. Daryl Anselmo, a creative director turned digital artist, has been experimenting with the technology since its early days, posting an AI-generated video every day since 2021. He tells me that uses a wide range of tools, including Kling, Luma, and Midjourney, and is constantly iterating. To him, testing the boundaries of these AI tools is sometimes itself the reward. “I would like to think there are impossible things that you could not do before that are still yet to be discovered. That is exciting to me,” he says.

Anselmo has collected his daily creations over the past four years into an art project, titled AI Slop, that has been exhibited in multiple galleries, including the Grand Palais Immersif in Paris. There’s obvious attention to mood and composition. Some clips feel like something closer to an art-house vignette than a throwaway meme. Over time, Anselmo’s project has taken a darker turn as his subjects shift from landscapes and interior design toward more of the body horror that drew Garibay in. 

His breakout piece, feel the agi, shows a hyperrealistic bot peeling open its own skull. Another video he shared recently features a midnight diner populated by anthropomorphized Tater Tots, titled Tot and Bothered; with its vintage palette and slow, mystical soundtrack, the piece feels like a late-night fever dream. 

One further benefit of these AI systems is that they make it easier for creators to build recurring spaces and casts of characters that function like informal franchises. Lim, for instance, is the creator of a popular AI video account called Niceaunties, inspired by the “auntie culture” in Singapore, where she’s from.

“The word ‘aunties’ often has a slightly negative connotation in Singaporean culture. They are portrayed as old-fashioned, naggy, and lacking boundaries. But they are also so resourceful, funny, and at ease with themselves,” she says. “I want to create a world where it’s different for them.” 

Her cheeky, playful videos show elderly Asian women merging with fruits, other objects, and architecture, or just living their best lives in a fantasy world. A viral video called Auntlantis, which has racked up 13.5 million views on Instagram, imagines silver-haired aunties as industrial mermaids working in an underwater trash-processing plant.  

There’s also Granny Spills, an AI video account that features a glamorous, sassy old lady spitting hot takes and life advice to a street interviewer. It gained 1.8 million Instagram followers within three months of launch, posting new videos almost every day. Although the granny’s face looks slightly different in every video, the pink color scheme and her outfit stay mostly consistent. Creators Eric Suerez and Adam Vaserstein tell me that their entire workflow is powered by AI, from writing the script to constructing the scenes. Their role, as a result, becomes close to creative directing.

@grannyspills

These projects often spin off merch, miniseries, and branded universes. The creators of Granny Spills, for example, have expanded their network, creating a Black granny as well as an Asian granny to cater to different audiences. The grannies now appear in crossover videos, as if they share the same fictional universe, pushing traffic between channels. 

In the same vein, it’s now more possible than ever to participate in an online trend. Consider  “Italian brainrot,” which went viral earlier this year. Beloved by Gen Z and Gen Alpha, these videos feature human–animal–object hybrids with pseudo-Italian names like “Bombardiro Crocodilo” and “Tralalero Tralala.” According to Know Your Meme, the craze began with a few viral TikTok sounds in fake Italian. Soon, a lot of people were participating in what felt like a massive collaborative hallucination, inventing characters, backstories, and worldviews for an ever-expanding absurdist universe. 

@patapimai

“Italian brainrot was great when it first hit,” says Denim Mazuki, a software developer and content creator who has been following the trend. “It was the collective lore-building that made it wonderful. Everyone added a piece. The characters were not owned by a studio or a single creator—they were made by the chronically online users.” 

This trend and others are further enabled by specialized and sophisticated new tools—like OpenArt, a platform designed not just for video generation but for video storytelling, which gives users frame-to-frame control over a developing narrative.

Making a video on OpenArt is straightforward: Users start with a few AI-generated character images and a line of text as simple as “cat dancing in a park.” The platform then spins out a scene breakdown that users can tweak act by act, and they can run it through multiple mainstream models and compare the results to see which look best.

OpenArt cofounders Coco Mao and Chloe Fang tell me they sponsored tutorial videos and created quick-start templates to capitalize specifically on the trend of regular people wanting to get in on Italian brainrot. They say more than 80% of their users have no artistic background. 

In defense of slop

The current use of the word “slop” online traces back to the early 2010s on 4chan, a forum known for its insular and often toxic in-jokes. As the term has spread, its meaning has evolved; it’s now a kind of derogatory slur for anything that feels like low-quality mass production aimed at an unsuspecting public, says Adam Aleksic, an internet linguist. People now slap it onto everything from salad bowls to meaningless work reports.

But even with that broadened usage, AI remains the first association: “slop” has become a convenient shorthand for dismissing almost any AI-generated output, regardless of its actual quality. The Cambridge Dictionary’s new sense of “slop” will almost certainly cement this perception, describing it as “content on the internet that is of very low quality, especially when it is created by AI.”   

Perhaps unsurprisingly, the word has become a charged label among AI creators. 

Anselmo embraces it semi-ironically, hence the title of his yearslong art project. “I see this series as an experimental sketchbook,” he says. “I am working with the slop, pushing the models, breaking them, and developing a new visual language. I have no shame that I am deep into AI.” Anselmo says that he does not concern himself with whether his work is “art.”

Garibay, the creator of the viral video where a human face emerged from a pot of physical slop, uses the label playfully. “The AI slop art is really just a lot of weird glitchy stuff that happens, and there’s not really a lot of depth usually behind it, besides the shock value,” he says. “But you will find out really fast that there is a heck of a lot more involved, if you want a higher-end result.” 

That’s largely in line with what Suerez and Vaserstein, the creators of Granny Spills, tell me. They actually hate it when their work is called slop, given the way the term is often used to dismiss AI-generated content out of hand. It feels disrespectful of their creative input, they say. Even though they do not write the scripts or paint the frames, they say they are making legitimate artistic choices. 

Indeed, for most of the creators I spoke to, making AI content is rarely a one-click process. They tell me that it takes skill, trial and error, and a strong sense of taste to consistently get the visuals they want. Lim says a single one-minute video can take hours, sometimes even days, to make. Anselmo, for his part, takes pride in actively pushing the model rather than passively accepting its output. “There’s just so many things that you can do with it that go well beyond ‘Oh, way to go, you typed in a prompt,’” he says. Ultimately, slop evokes a lot of feelings. Aleksic puts it well: “There’s a feeling of guilt on the user end for enjoying something that you know to be lowbrow. There’s a feeling of anger toward the creator for making something that is not up to your content expectations, and all the meantime, there’s a pervasive algorithmic anxiety hanging over us. We know that the algorithm and the platforms are to blame for the distribution of this slop.”

And that anxiety long predates generative AI. We’ve been living for years with the low-grade dread of being nudged, of having our taste engineered and our attention herded, so it’s not surprising that the anger latches onto the newest, most visible culprit. Sometimes it is misplaced, sure, but I also get the urge to assert human agency against a new force that seems to push all of us away from what we know and toward something we didn’t exactly choose.

But the negative association has real harm for the earlier adopters. Every AI video creator I spoke to described receiving hateful messages and comments simply for using these tools at all. These messages accuse AI creators of taking opportunities away from artists already struggling to make a living, and some dismiss their work as “grifting” and “garbage.” The backlash, of course, did not come out of nowhere. A Brookings study of one major freelance marketplace found that after new generative-AI tools launched in 2022, freelancers in AI-exposed occupations saw about 2% decline in contracts and a 5% drop in earnings. 

“The phrase ‘AI slop’ implies, like, a certain ease of creation that really bothers a lot of people—understandably, because [making AI-generated videos] doesn’t incorporate the artistic labor that we typically associate with contemporary art,” says Mindy Seu, a researcher, artist, and associate professor in digital arts at UCLA. 

At the root of the conflict here is that the use of AI in art is still nascent; there are few best practices and almost no guardrails. And there’s a kind of shame involved—one I recognize when I find myself lingering on bad AI content. 

Historically, new technology has always carried a whiff of stigma when it first appears, especially in creative fields where it seems to encroach on a previously manual craft. Seu says that digital art, internet art, and new media have been slow to gain recognition from cultural institutions, which remain key arbiters of what counts as “serious” or “relevant” art. 

For many artists, AI now sits in that same lineage: “Every big advance in technology yields the question ‘What is the role of the artist?’” she says. This is true even if creators are not seeing it as a replacement for authorship but simply as another way to create. 

Mao, the OpenArt founder, believes that learning how to use generative video tools will be crucial for future content creators, much as learning Photoshop was almost synonymous with graphic design for a generation. “It is a skill to be learned and mastered,” she says.

There is a generous reading of the phenomenon so many people call AI slop, which is that it is a kind of democratization. A rare skill shifts away from craftsmanship to something closer to creative direction: being able to describe what you want with enough linguistic precision, and to anchor it in references the model is likely to understand. You have to know how to ask, and what to point to. In that sense, discernment and critique sit closer to the center of the process than ever before.

It’s not just about creative direction, though, but about the human intention behind the creation. “It’s very easy to copy the style,” Lim says. “It’s very easy to make, like, old Asian women doing different things, but they [imitators] don’t understand why I’m doing it … Even when people try to imitate that, they don’t have that consistency.”

“It’s the idea behind AI creation that makes it interesting to look at,” says Zach Lieberman, a professor at the MIT Media Lab who leads a research group called Future Sketches, where members explore code-enabled images. Lieberman, who has been posting daily sketches generated by code for years, tells me that mathematical logic is not the enemy of beauty. He echoes Mao in saying that a younger generation will inevitably see AI as just another tool in the toolbox. Still, he feels uneasy: By relying so heavily on black-box AI models, artists lose some of the direct control over output that they’ve traditionally enjoyed.

A new online culture

For many people, AI slop is simply everything they already resent about the internet, turned up: ugly, noisy, and crowding out human work. It’s only possible because it’s been trained to take all creative work and make it fodder, stripped of origin, aura, or credit, and blended into something engineered to be mathematically average—arguably perfectly mediocre, by design. Charles Pulliam-Moore, a writer for The Verge, calls this the “formulaic derivativeness” that already defines so much internet culture: unimaginative, unoriginal, and uninteresting. 

But I love internet culture, and I have for a long time. Even at its worst, it’s bad in an interesting way: It offers a corner for every kind of obsession and invites you to add your own. Years of being chronically online have taught me that the real logic of slop consumption isn’t mastery but a kind of submission. As a user, I have almost no leverage over platforms or algorithms; I can’t really change how they work. Submission, though, doesn’t mean giving up. It’s more like recognizing that the tide is stronger than you and choosing to let it carry you. Good scrolling isn’t about control anyway. It’s closer to surfing, and sometimes you wash up somewhere ridiculous, but not entirely alone.

Mass-produced click-bait content has always been around. What’s new is that we can now watch it being generated in real time, on a scale that would have been unimaginable before. And the way we respond to it in turn shapes new content (see the trampoline-bouncing bunnies) and more culture and so on. Perhaps AI slop is born of submission to algorithmic logic. It’s unserious, surreal, and spectacular in ways that mirror our relationship to the internet itself. It is so banal—so aggressively, inhumanly mediocre—that it loops back around and becomes compelling. 

To “love AI slop” is to admit the internet is broken, that the infrastructure of culture is opportunistic and extractive. But even in that wreckage, people still find ways to play, laugh, and make meaning. 

Earlier this fall, months after I was briefly fooled by the bunny video, I was scrolling on Rednote and landed on videos by Mu Tianran, a Chinese creator who acts out weird skits that mimic AI slop. In one widely circulated clip, he plays a street interviewer asking other actors, “Do you know you are AI generated?”—parodying an earlier wave of AI-generated street interviews. The actors’ responses seem so AI, but of course they’re not: Eyes are fixed just off-camera, their laughter a beat too slow, their movements slightly wrong. 

Watching this, it was hard to believe that AI was about to snuff out human creativity. If anything, it has handed people a new style to inhabit and mock, another texture to play with. Maybe it’s all fine. Maybe the urge to imitate, remix, and joke is still stubbornly human, and AI cannot possibly take it away. 

Researchers are getting organoids pregnant with human embryos

At first glance, it looks like the start of a human pregnancy: A ball-shaped embryo presses gently into the receptive lining of the uterus and then grips tight, burrowing in as the first tendrils of a future placenta appear. 

This is implantation—the moment that pregnancy officially begins.

Only none of it is happening inside a body. These images were captured in a Beijing laboratory, inside a microfluidic chip, as scientists watched the scene unfold.

a microfluidic chip with channel measurements marked in mm
This transparent microfluidic chip is used to grow an organoid that mimics the lining of a uterus.
COURTESY OF THE RESEARCHERS

In three papers published this week by Cell Press, scientists are reporting what they call the most accurate efforts yet to mimic the first moments of pregnancy in the lab. They’ve taken human embryos from IVF centers and let these merge with “organoids” made of endometrial cells, which form the lining of the uterus.

The reports—two from China and a third involving a collaboration among researchers in the United Kingdom, Spain, and the US—show how scientists are using engineered tissues to better understand early pregnancy and potentially improve IVF outcomes.

“You have an embryo and the endometrial organoid together,” says Jun Wu, a biologist at the University of Texas Southwestern Medical Center, in Dallas, who contributed to both Chinese reports. “That’s the overarching message of all three papers.”

According to the papers, these 3D combinations are the most complete re-creations yet of the first days of pregnancy and should be useful for studying why IVF treatments often fail.

In each case, the experiments were stopped when the embryos were two weeks old, if not sooner. That is due to legal and ethical rules that typically restrict scientists from going any further than 14 days.

In your basic IVF procedure, an egg is fertilized in the lab and allowed to develop into a spherical embryo called a blastocyst—a process that takes a few days. That blastocyst then gets put into a patient’s uterus in the hope it will establish itself there and ultimately become a baby.

two embryos growing in placental tissue
Two blastoids, or artificial embryos (circles), grow inside an organoid.
COURTESY OF THE RESEARCHERS

But that’s a common failure point. Many patients will learn that their IVF procedure didn’t work because an embryo never attached.

In the new reports, it’s that initial bond between mother and embryo that is being reproduced in the lab. “IVF means in vitro fertilization, but now this is the stage of in vitro implantation,” says Matteo Molè, a biologist at Stanford University whose results with collaborators in Europe are among those published today. “Considering that implantation is a barrier [to pregnancy], we have the potential to increase the success rate if we can model it in the laboratory.”

Normally implantation is entirely hidden from view because it occurs in someone’s uterus, says Hongmei Wang, a developmental biologist at the Beijing Institute for Stem Cell and Regenerative Medicine, who co-led the effort there. Wang often studies monkeys because she can interrupt their pregnancies to collect the tissues she needs to see. “We’ve always hoped to understand human embryo implantation, but we have lacked a way to do so,” she says. “It’s all happening in the uterus.”

In the Beijing study, researchers tested about 50 donated IVF embryos, but they also ran a thousand more experiments using so-called blastoids. The latter are mimics of early-stage human embryos manufactured from stem cells. Blastoids are easy to make in large numbers and, since they aren’t true embryos, don’t have as many ethical rules on their use.

“The question was, if we have these blastoids, what can we use them for?” says Leqian Yu, the senior author of the report from the Beijing Institute. “The obvious next step was implantation. So how do you do that?”

For the Beijing team, the answer was to build a soft silicone chamber with tiny channels to add nutrients and a space to grow the uterine organoid. After that, blastoids—or real embryos—could be introduced through a window in the device, so the “pregnancy” could start.

“The key question we want to try to answer is what is the first cross-talk between embryo and mother,” says Yu. “I think this is maybe the first time we can see the entire process.”

Medical applications

This isn’t the first time researchers have tried using organoids for this kind of research. At least two startup companies have raised funds to commercialize similar systems—in some cases presenting the organoids as a tool to predict IVF success. In addition to Dawn Bio, a startup based in Vienna, there is Simbryo Technologies, in Houston, which last month said it would begin offering “personalized” predictions for IVF patients using blastoids and endometrial organoids.

To do that test, doctors will take a biopsy of a patient’s uterine lining and grow organoids from it. After that, blastoids will be added to the organoids to gauge whether a woman is likely to be able to support a pregnancy or not. If the blastoids don’t start to implant, it could mean the patient’s uterus isn’t receptive and is the reason IVF isn’t working.

The Beijing team thinks the pregnancy organoids could also be used to identify drugs that might help those patients. In their paper, they describe how they made organoids out of tissue taken from women who’ve had repeated IVF failures. Then they tested 1,119 approved drugs on those samples to see if anything improved.

Several seemed to have helpful effects. One chemical, avobenzone, an ingredient in some types of sunblock, increased the chance that a blastoid would start implanting from just 5% of the time to around 25% of the time. Yu says his center hopes to eventually start a clinical trial if they can find the right drug to try. 

Artificial womb?

The Beijing group is working on ways to improve the organoid system so that it’s even more realistic. Right now, it lacks important cell types, including immune cells and a blood supply. Yu says a next step he’s working on is to add blood vessels and tiny pumps to his chip device, so that he can give the organoids a kind of rudimentary circulation.

This means that in the near future, blastoids or embryos could likely be grown longer, raising questions about how far scientists will be able to take pregnancy in the lab. “I think this technology does raise the possibility of growing things longer,” says Wu, who says some view the research as an initial step toward creating babies entirely outside the body.

However, Wu says incubating a human to term in the laboratory remains impossible, for the time being. “This technology is certainly related to ectogenesis, or development outside the body,” he says. “But I don’t think it’s anywhere near an artificial womb. That’s still science fiction.”

GSC Groups Keywords as AI Queries Expand

Google Search Console’s “Insights” section no longer shows click trends for individual keywords. It now displays trends for keyword groups, once available only to high-traffic sites.

Selecting any group of keywords takes you to the Performance section with the regex filter activated to show details.

Many marketers believe the future of organic search monitoring is keyword groups. Consumers’ queries are becoming longer and more diverse as they interact with genAI platforms such as ChatGPT and Google AI Mode. Hence tracking individual words is becoming ineffective.

Here’s how to benefit from Search Console’s query grouping feature.

Screenshot of Search Console's Insights keyword trends report.

Search Console’s “Insights” section now displays click trends only by keyword group.

Analyze SERPs

Identify new sections or features on search engine result pages impacting your site’s performance.

If an important keyword group (such as brand-name queries) is trending down, run a live search and analyze the results (on desktop and mobile). A loss of brand visibility often results from advertising: a competitor bidding on the terms. To combat, adjust your paid search strategy (or report policy-breaking ads).

A new AI Overview for a vital keyword could also reduce visibility and clicks. The loss is not reversible unless Google changes the SERP.

For branded searches, at least ensure the AI Overview does not misrepresent your business. If it does, check all URLs it cites, identify the one with incorrect info, and try to correct it. Also, clarify that point on your own pages, especially if those rank for that brand term.

Fix Lagging Groups

Trending-down keyword groups may need work. Select the keyword group in Search Console to load it in the Performance section. Then click the “Pages” tab. Here you can see the URLs that rank for this cluster.

Tactics that could elevate SERP visibility for the entire cluster include:

Search Console may display ecommerce content and product pages in the same cluster. This is a great opportunity:

  • Link related product and content pages.
  • Identify product opportunities, those not included in related ranking content.
  • Create product categories to match the cluster.
Screenshot of Search Console's Pages tab.

Click the “Pages” tab in the Performance section to see the URLs that rank for a cluster.

Content Opportunities

Upward-trending keyword groups usually signal content opportunities.

Use keyword research tools to uncover related topics, such as a new demographic. Or update older relevant content and link it to a popular, related version.

Rising clusters validate a broader content strategy. Optimize further with supporting FAQs, comparison guides, or video tutorials.

10 tips to improve the quality of your page

Is your page not attracting the number of people you thought it would? Or are you wondering what you can improve to get your page higher up in the search results? And to get people to stay on (and come back to) your site? There are a few things you can do to give your page a better chance at performing well. In this blog post, we’ll discuss how you can determine which pages could use some extra love and what you can do to turn them into high-quality pages!

It is important to realize that content quality can have a big impact on your business and online findability. Especially since Google announced its helpful content update, your rankings might suffer if you have too much low-quality content. It’s not just about using the right keyword; search engines nowadays look at the whole picture. So it’s important to identify those low-quality pages and work your magic.

How to determine page quality

It’s important to determine which pages need improving and in what order. It can be tempting to just get started with the first page that comes to mind, but take some time to work out how your pages perform. This helps you prioritize and decide on what page needs your attention first.

Have a look at the metrics

You probably know your audience to some degree, but it’s unlikely that you know exactly what they want. Or how they search online and navigate through your site. Even if you have a hunch or hear from them regularly, make sure to look at the data to validate what people do on your site and where you can improve. A great tool to do this is Google Analytics. It can tell you how many people visit your site and where they’re coming from. Additionally, which pages are being visited the most, and how long people tend to stay on each page. All of this helps you determine the quality of your individual pages. So it’s well worth the effort to start learning about Google Analytics.

Use the Yoast SEO content analysis

Yoast SEO cleverly analyses your content to help you identify problems. Your content might have readability issues, making it hard for users to understand what you’re saying. Or you might have overused your keywords, making your text seem unnatural and spammy. Using Yoast SEO, you can easily see which pages and posts need improvement by looking at the traffic lights in the overview.

Yoast SEO shows red and orange traffic lights in the overview to highlight content issues

Identify low-quality pages with Screaming Frog

A tool you can use to easily identify low-quality content is Screaming Frog SEO Spider. When you run a query for your website in the SEO spider, you will get a list of all the URLs on your site. Now scroll through that list and visit every URL that makes no sense to you. The fact is, low-quality pages often occur in groups, rather than as a single page.

Think along the lines of old .html pages, where you end your URLs with a trailing slash now. Think about your attachment pages or anything with too many numbers in it. These should all make you feel suspicious. Visit the page and see if it displays low-quality content that shouldn’t be on Google. Test if these pages are indexed and check if there are more pages like them. Take a critical look at the pages you’ve found.

10 tips to directly improve page quality

Once you’ve assessed the quality of your individual pages, it’s a good idea to create a list prioritizing the pages you want to work on first. After that, the real fun begins. Let’s take a look at the first 10 tips to improve your page quality.

1. Decide on what you want to do with the page

First things first, figure out what you want to do with your page. For pages that are no longer up to date, ask yourself the following question: Can you update the page by making changes to it? Great, then you can go to the second tip on this list. But for pages that no longer have any business being on your site anymore, it might be best to remove them. Decide whether you want to update or delete the page.

Chances are that you’ll also resurface a few outdated pages that don’t need to be shown in Google, even if you want to keep them on your site. On these pages you can use the noindex tag. If a low-quality page still holds relevant links to other parts of your website and has some traffic due to, for instance, links from other websites, you can use noindex, follow in your robots meta tag. This way, Google can find the page, follow the relevant links, but it will keep the page itself out of the search results.

Advanced tab in Yoast SEO to set page to noindex or nofollow
You can find these indexing options in the Advanced tab in the Yoast SEO meta box

2. Think about search intent

When you want to improve the quality of a page, it’s good practice to take search intent into consideration. Search intent (or user intent) is the term used to describe the purpose of an online search. To be more exact, it’s the reason why someone conducts a specific search. Over the years, Google has worked hard to improve its algorithm to be able to determine people’s search intent. That’s why you need to think about matching your content to someone’s search intent when they land on your page.

The reason we’re discussing this here is that you want to make sure your pages show up for the right search intent. When someone is looking for information, you don’t want to send them to your product page right away. They’re probably not ready for that yet. And when someone does have a transactional intent, you don’t want them to land on one of your blog posts discussing the latest news. In that case, you want to ensure they go to the right product (or category) page right away.

Read more: Using the search results to create great intent-based content »

3. Create unique content

An important factor that determines the quality of your page is content. There are a few basics that you need to tackle right away. For one, always base your content on the right keyphrases by conducting keyword research. Also, if your low-quality page doesn’t have a lot of text and doesn’t hold a lot of information, this could be considered thin content. Your users and search engines aren’t fans of this type of content, as it has little or no value to them. So make sure to write extensively on the topic you want to be found on.

Try to be critical of your writing and become the source for people instead of copying another source. Although it’s always good to keep an eye on your competition and the content they’re producing, make sure to have your own voice. If you write unique, insightful, useful content, people will be much more inclined to actually read it or link to it. Google will see that content as an addition to its index.

4. Show E-E-A-T

Everyone can own a website nowadays. Which is great, as this opens up the web for everyone. But this online growth has also resulted in trust issues when it comes to sites you’re not familiar with yet. That’s why it’s crucial to show readers, and search engines, that you can be trusted and that you’re an authority in your field. This doesn’t just help your pages show up in the search results; it also helps users reach the level of trust they need to do business with you online.

Google is working hard to recognize and reward high-quality content, and this is where E-E-A-T also comes into play. This acronym stands for Experience, Expertise, Authoritativeness, and Trustworthiness. This core concept is outlined in their Search Quality Raters guidelines and is used to evaluate online content. Meaning that your content will be judged as higher quality if you show experience, expertise, authoritativeness and trustworthiness. All of these will enhance the quality of your pages while helping you build a strong brand online.

5. Work on your site reputation

Another factor that is closely related to trustworthiness is the reputation of your website. This is something search engines also take into account when determining the quality of the pages on your site. But how do they determine your reputation? By analyzing what others are saying about you online. For example, user ratings about your site and how positive these are. But also other experts or established sites mentioning your business on their site. Or any other information about your business or authors mentioned on other sites.

6. Link to and from your page

For people and search engines to be able to find your page, you need to ensure that you link to it. From other pages on your website that are related to the one you’re currently working on. So make sure to work on your internal linking and connect the content on your website to each other.

That being said, it’s important not to overdo it and link to every page you own in one post. Always keep the user in mind. So make sure to link to pages or posts that are actually relevant and that you can link to naturally. Our plugin has a great internal linking tool that suggests related content for every post or page.

Tips to improve site performance

We still have 4 tips to go, and they’re all related to the performance of your site. Some of them may take some more time, but these aspects are essential if you want to improve the quality of your pages. Not just for the search engines, but especially for your users.

7. Improve your site’s speed

The speed of your website determines whether you get a good ranking in Google, and its importance keeps growing. Why? Because faster sites are easier for search engines to process. And because search engines know that users don’t like slow websites. Users tend to buy less from slower sites and don’t read and engage as much as they would on a site with great site speed. So work on improving your site speed, you’ll be thankful for it later. Google also made page experience a ranking factor, making speed and user experience on your site even more important.

8. Consider user experience

User experience, also called UX, is all about how users experience a site or product. Search engines want to provide their users with the best results for their search queries. The best result doesn’t only mean the best answer, but also the best experience. So even if you’ve written an excellent answer in a post, but your site is slow or a mess, Google won’t consider your post the best answer.

Consider the goal of your site and its specific pages. What do you want visitors to do on your page? Buy stuff? Read your articles? Your design and content should support this goal. Having a clear goal in mind will also help you prioritize the improvements for your site. This ties in with the search intent of a certain page, but you should also consider whether the design and structure of your pages support the goal of your site. And how does your site work on mobile devices?

9. Don’t forget about accessibility

The last question mentions your mobile site, and with good reason. Mobile is such a big part of most people’s lives nowadays that you don’t have the luxury of not having a well-performing mobile site. Make sure your site works on different devices and in different browsers to cater to every one of your site visitors. We have an ultimate guide on Mobile SEO that helps you determine the state of your mobile website and what you can still improve on.

10. Keep your site healthy and safe

The safety and health of your site is important for the visibility of your site, but it’s also important for you and your business. So make sure to check how safe your site is right now and make the necessary improvements to keep your site happy and healthy. If you’re using WordPress, we have blog posts that help you with your site’s health and your security in a few easy steps.

Time to improve that page quality!

All of these tips will help you improve the quality of your pages. And give Google a website that truly helps their visitors, and in the end, simply answers their question. As soon as you have cleaned up all that low-quality content and all high-quality pages surface in Google, you know you’ve made yet another sustainable step towards better rankings. Have fun!

Keep reading: What is quality content and how do you create it? »

Google Reveals The Top Searches Of 2025 via @sejournal, @MattGSouthern

In 2025, Google’s AI tool Gemini topped global searches. People tracked cricket matches between India and England, looked up details on the new Pope, and searched for information about Iran and the TikTok ban. They followed LA fires and government shutdowns.

But between the headlines, they also looked up Pedro Pascal and Mikey Madison. They wanted to make hot honey and marry me chicken. They planned trips to Prague and Edinburgh. They searched for bookstores from Livraria Lello in Porto to Powell’s in Portland.

Google’s Year in Search tracks what spiked. These lists show queries that grew the fastest relative to 2024, ranging from breaking news to entertainment, sports, and lifestyle. Together, they present a picture of what captured attention throughout the year.

Top Searches Of 2025

Google’s AI assistant Gemini became the top trending search globally, showing how widely AI tools were embraced throughout the year. The rest of the top 10 was filled with sports, with cricket matches between India and England, the Club World Cup, and the Asia Cup capturing a lot of public interest.

The global top 10 trending searches were:

Global top 10:

  1. Gemini
  2. India vs England
  3. Charlie Kirk
  4. Club World Cup
  5. India vs Australia
  6. Deepseek
  7. Asia Cup
  8. Iran
  9. iPhone17
  10. Pakistan and India

The US list reflected different priorities and diverged from global trends, with Charlie Kirk at the top and entertainment properties ranking highly. KPop Demon Hunters secured the second position.

The US top 10 trending searches were:

US top 10:

  1. Charlie Kirk
  2. KPop Demon Hunters
  3. Labubu
  4. iPhone 17
  5. One Big Beautiful Bill Act
  6. Zohran Mamdani
  7. DeepSeek
  8. Government shutdown
  9. FIFA Club World Cup
  10. Tariffs

News & Current Events

Natural disasters and political events shaped what news topics people were searching for. The LA Fires, Hurricane Melissa, and the TikTok ban drew worldwide interest, while in the US, folks were most often searching about topics like the One Big Beautiful Bill Act and the government shutdown.

Global top 10:

  1. Charlie Kirk assassination
  2. Iran
  3. US Government Shutdown
  4. New Pope chosen
  5. LA Fires
  6. Hurricane Melissa
  7. TikTok ban
  8. Zohran Mamdani elected
  9. USAID
  10. Kamchatka Earthquake and Tsunami

US top 10:

  1. One Big Beautiful Bill Act
  2. Government shutdown
  3. Charlie Kirk assasination
  4. Tariffs
  5. No Kings protest
  6. Los Angles fires
  7. New Pope chosen
  8. Epstein files
  9. U.S. Presidential Inauguration
  10. Hurricane Melissa

AI-Generated Content Leads US Trends

AI-generated content captured everyone’s attention in the US, with AI-created images and characters popping up all over different categories. The viral AI Barbie, AI action figures, and Ghibli-style AI art topped this year’s trends.

The top US trends included:

  1. AI action figure
  2. AI Barbie
  3. Holy airball
  4. AI Ghostface
  5. AI Polaroid
  6. Chicken jockey
  7. Bacon avocado
  8. Anxiety dance
  9. Unfortunately, I do love
  10. Ghibli

People

Music artists and political figures were among the most searched people worldwide. d4vd, Kendrick Lamar, and the newly elected Pope Leo XIV attracted the most international attention. In the US, searches mainly centered on political appointees such as Zohran Mamdani and Karoline Leavitt.

Global top 10:

  1. d4vd
  2. Kendrick Lamar
  3. Jimmy Kimmel
  4. Tyler Robinson
  5. Pope Leo XIV
  6. Vaibhav Sooryavanshi
  7. Shedeur Sanders
  8. Bianca Censori
  9. Zohran Mamdani
  10. Greta Thunberg

US top 10:

  1. Zohran Mamdani
  2. Tyler Robinson
  3. d4vd
  4. Erika Kirk
  5. Pope Leo XIV
  6. Shedeur Sanders
  7. Bonnie Blue
  8. Karoline Leavitt
  9. Andy Byron
  10. Jimmy Kimmel

    Entertainment

    Actors

    Breakthrough performances drove increased actor searches. Mikey Madison saw a spike in global searches after her acclaimed role in Anora, while Pedro Pascal led searches in the US.

    Global top 5:

    1. Mikey Madison
    2. Lewis Pullman
    3. Isabela Merced
    4. Song Ji Woo
    5. Kaitlyn Dever

    US top 5:

    1. Pedro Pascal
    2. Malachi Barton
    3. Walton Goggins
    4. Pamela Anderson
    5. Charlie Sheen

    Movies

    Expected franchise entries and original films topped movie searches. Anora was the top globally, while KPop Demon Hunters gained US popularity, alongside major releases such as The Minecraft Movie and Thunderbolts.

    Global top 5:

    1. Anora
    2. Superman
    3. Minecraft Movie
    4. Thunderbolts*
    5. Sinners

    US top 5:

    1. KPop Demon Hunters
    2. Sinners
    3. The Minecraft Movie
    4. Happy Gilmore 2
    5. Thunderbolts*

        Books

        Contemporary romance and classic literature were the most searched genres. Colleen Hoover’s “Regretting You” and Rebecca Yarros’s “Onyx Storm” topped both global and US charts, while George Orwell’s “Animal Farm” and “1984” saw a resurgence in popularity.

        Global top 10:

        1. Regretting You – Colleen Hoover
        2. Onyx Storm – Rebecca Yarros
        3. Lights Out – Navessa Allen
        4. The Summer I Turned Pretty – Jenny Han
        5. The Housemaid – Freida McFadden
        6. Frankenstein – Mary Shelley
        7. It – Stephen King
        8. Animal Farm – George Orwell
        9. The Witcher – Andrzej Sapkowski
        10. Diary Of A Wimpy Kid – Jeff Kinney

        US top 10:

        1. Regretting You – Colleen Hoover
        2. Onyx Storm – Rebecca Yarros
        3. Lights Out – Navessa Allen
        4. The Summer I Turned Pretty – Jenny Han
        5. The Housemaid – Freida McFadden
        6. It – Stephen King
        7. Animal Farm – George Orwell
        8. The Great Gatsby – F. Scott Fitzgerald
        9. To Kill a Mockingbird – Harper Lee
        10. 1984 – George Orwell

        Podcasts

        Podcast searches were driven by political commentary and celebrity-hosted shows. The Charlie Kirk Show ranked first both worldwide and in the US, while sports podcast New Heights and Michelle Obama’s “IMO” gained attention in the US.

        Global top 10:

        1. The Charlie Kirk Show
        2. New Heights
        3. This Is Gavin Newsom
        4. Khloé In Wonder Land
        5. Good Hang With Amy Poehler
        6. Candace
        7. The Meidastouch Podcast
        8. The Ruthless Podcast
        9. The Venus Podcast
        10. The Mel Robbins Podcast

        US top 10:

        1. New Heights
        2. The Charlie Kirk Show
        3. IMO with Michelle Obama and Craig Davidson
        4. This Is Gavin Newsom
        5. Good Hang With Amy Poehler
        6. Khloé In Wonder Land
        7. The Severance Podcast
        8. The Rosary in a Year
        9. Unbothered
        10. The Bryce Crawford Podcast

        Sports Events

        International soccer tournaments attracted the most global sports searches. The FIFA Club World Cup, Asia Cup, and ICC Champions Trophy were the top interests worldwide, while in the US, searches centered on domestic events like the Ryder Cup and UFC championships.

        Global top 10:

        1. FIFA Club World Cup
        2. Asia Cup
        3. ICC Champions Trophy
        4. ICC Women’s World Cup
        5. Ryder Cup
        6. EuroBasket
        7. Concacaf Gold Cup
        8. 4 Nations Face-Off
        9. UFC 313
        10. UFC 311

        US top 10:

        1. Ryder Cup
        2. 4 Nations Face-Off
        3. UFC 313
        4. UFC 311
        5. College Football Playoff
        6. Super Bowl LX
        7. NBA Finals
        8. World Series
        9. Stanley Cup Finals
        10. March Madness

        Lifestyle And Gaming

        Anticipated game releases led search trends. Arc Raiders was the most-searched title globally, while Clair Obscur: Expedition 33 was the top search in the US, alongside popular titles such as Battlefield 6 and Hollow Knight: Silksong.

        Global top 5 games:

        1. Arc Raiders
        2. Battlefield 6
        3. Strands
        4. Split Fiction
        5. Clair Obscur: Expedition 33

        US top 5 games:

        1. Clair Obscur: Expedition 33
        2. Battlefield 6
        3. Hollow Knight: Silksong
        4. ARC Raiders
        5. The Elder Scrolls IV: Oblivion Remastered

          Music (US Only)

          Emerging artists and well-known musicians drove music searches. d4vd led in musician searches, whereas Taylor Swift led song rankings with various tracks, including “Wood” and “The Fate of Ophelia.”

          Top 5 musicians:

          1. d4vd
          2. KATSEYE
          3. Bad Bunny
          4. Sombr
          5. Doechii

          Top 5 songs:

          1. Wood – Taylor Swift
          2. DtMF – Bad Bunny
          3. Golden – HUNTR/X
          4. The Fate of Ophelia – Taylor Swift
          5. Father Figure – Taylor Swift

          Travel (US Only)

          Major cities and popular European destinations drove travel itinerary searches. Boston, Seattle, and Tokyo led domestic travel plans, while Prague and Edinburgh were notably popular for European trips.

          Top 10 travel itinerary searches:

          1. Boston
          2. Seattle
          3. Tokyo
          4. New York
          5. Prague
          6. London
          7. San Diego
          8. Acadia National Park
          9. Edinburgh
          10. Miami

            Google Maps

            Google Maps data represents the most-searched locations on Maps in 2025.

            Bookstores

            Historic and iconic bookstores drew worldwide attention on Google Maps. Portugal’s Livraria Lello and Tokyo’s Animate Ikebukuro were the most searched internationally, while Powell’s City of Books in Portland ranked highest in US bookstore interest.

            Global top 5:

            1. Livraria Lello, Porto District, Portugal
            2. animate Ikebukuro main store, Tokyo, Japan
            3. El Ateneo Grand Splendid, Buenos Aires, Argentina
            4. Shakespeare and Company, Île-de-France, France
            5. Libreria Acqua Alta, Veneto, Italy

            US top 5:

            1. Powell’s City of Books, Portland, Oregon
            2. Strand Book Store, New York, New York
            3. The Last Bookstore, Los Angeles, California
            4. Kinokuniya New York, New York, New York
            5. Stanford University Bookstore, Stanford, California

                Looking Back

                That’s what caught attention in 2025. People searched for breaking news about natural disasters and political changes. They tracked sports tournaments and looked up new AI tools. They followed major world events.

                And between those searches, they looked up actors after breakthrough performances, found recipes they saw on social feeds, and planned trips to places they’d been thinking about for years.

                The trends don’t tell you what mattered most. They tell you what people were curious about when they had a spare moment, whether that was understanding a major news event or finding the perfect travel itinerary.

                You can watch the full Google Year In Search video below:

                The full Year in Search data is at trends.withgoogle.com/year-in-search/2025.

                More resources:

                Ask An SEO: What Is The Threshold Between Keyword Stuffing & Being Optimized? via @sejournal, @rollerblader

                In this week’s Ask An SEO, Bre asks:

                “What is the threshold between keyword stuffing and being optimized? Is there a magic rule for how often to use your main keyword and related keywords in a 2,000-word page? Should the main keyword be in the Headers AND the body in the same section?”

                Great question!

                There is no such thing as “being optimized” when it comes to keywords and repetitions. This is similar to looking at “authority” scores for domains. The optimization scores you get are measurements based on what an SEO tool thinks gives a domain trust, and not the actual search engines or LLM and AI systems. The idea of a keyword needing to be repeated is from an SEO concept called keyword density, which is a result of SEO tools.

                Each tool would have a different way to say if you repeated a word or phrase enough for it to be “SEO friendly,” and because people trust the tools, they trust that this is a valid ranking factor or signal for a search engine. It is not because the search engines do not pay attention to how many times a word is on a page or in a paragraph, as that doesn’t produce a good experience.

                Panda reduced the effectiveness of low-quality, keyword-stuffed content, and Google’s later advancements, BERT and MUM, allowed better understanding of context, relationships between terms, and the overall structure of a page. Google is now far better at interpreting meaning without relying on repeated exact-match keywords.

                With that said, keywords are important.

                Keywords help to send a signal to a search engine about the topic of the page. And they can be used in headers, within text, as internal links, within title tags, schema, and the URL structure. But worrying about using the keyword for SEO purposes can lead to trouble. So, let’s define keyword stuffing for the sake of this post.

                Keyword stuffing is when you force a keyword or keyword phrase into content, headers, and URLs for the sole purpose of SEO.  

                By forcing a keyword into a post, or forcing it into headers, you hurt the user experience. Although the search engine will know what you want to rank for, the language won’t feel natural. Instead of worrying about how many times you say the keyword, think about synonyms and other ways to say things that are easy to understand. Many search engines are getting better and better at understanding how topics, words, sentences, and phrases relate to one another. You don’t have to repeat the same words over and over anymore.

                If you Google the word “swimsuit,” you’ll likely see it in a couple of title tags, but also see “swimwear.” Now type “bathing suits” in, you’ll likely not see it in a ton of the title tags, but the title tags will say “swimwear” and other synonyms, even though “bathing suits” is a popular name for the same product.

                Now try “hairdresser near me,” and you’ll likely not see “hairdresser” in a lot of the results, but you will see “hair salon” and similar types of businesses. This is because search engines produce solutions to problems, and if they understand the page has the solution, you don’t need to keep repeating keywords.

                For example, instead of saying “keyword stuffing” in this post, I could say “overusing phrases for SEO.” It means the same thing. Readers on this column will get bored pretty fast if I keep saying keyword stuffing, and by mixing it up, I can keep their interest, and search engines are still able to determine it is one-in-the-same. This also applies to header tags.

                I don’t have any solid proof of this, but it seems to work well for our clients and the content we create, and it has worked for more than 10 years. If the main keyword phrase is in the H1 tag, whether it is a menu item or a blog post, we don’t worry about placing it in H2, H3, etc. I won’t be upset if the keyword shows up naturally, as that creates a good UX.

                The theory here is that headers carry the theme and topic through the sections below. If the top-level header has the word “blue” in it, I make the assumption that theme “blue” carries through the page and applies to the H2 tag as the H2 is a sub-topic of “blue.” “H2’s” for blue could be “t-shirts” and “shorts.”

                If this is true, by having the H1 be “blue” and the H2 be “shorts,” a search engine will know they are “blue shorts,” and I feel very confident users will too. They clicked blue or found a SERP for blue clothing, and they clicked shorts from the menu or found them from scrolling.

                If you stuff “blue” into each link and header, it is annoying for the user to see it over and over. But many sites that get penalized will have “blue cargo shorts,” “blue chino shorts,” “blue workout shorts,” etc. It looks nicer to just say the styles of shorts like “cargo” or “chino,” and search engines likely already know they’re blue because you had it in the H tag one level up. You also likely have the “blue” part in breadcrumbs, site structure, product descriptions, etc.

                One thing you definitely do not want to do is have a million footer links that match the navigation or are keyword-stuffed. This worked a long time ago, but now it is just spam. It doesn’t benefit the user; it is obvious to search engines you’re doing it for SEO. Sites that stuff keywords tend to use these outdated tactics too, so I want to include it here.

                I hope this helps answer your question about overusing specific topics or phrases. Doing this only makes the tool happy; it does not mean you’ll be creating a good UX for users or search engines. If you focus on writing for your consumer and incorporate a keyword or phrase naturally, you’ll likely be rewarded.

                More Resources:


                Featured Image: Paulo Bobita/Search Engine Journal

                Why Every Google Ads Account Needs To Run Scripts

                Most PPC marketers love talking about automation, Smart Bidding, and the latest AI-powered magic Google rolls out. But the truth is that none of those shiny features can save your account from the actual threats: human error, broken websites, overspending budgets, bad conversion data, brand safety violations … the list goes on and on.

                That’s where Google Ads scripts come in.

                Scripts are the unglamorous robots behind the scenes. They automate grunt work, protect your budget, enforce account hygiene, and alert you before a minor issue becomes a five-figure disaster. They’re free, easy to use, safe to test, and thanks to modern large language models, anyone can build or customize them – even without coding skills!

                If you manage Google Ads accounts and you’re not using scripts, you’re working too hard and taking unnecessary risks.

                I am here to tell you today: Every account should have Google Ads scripts running. Here’s why:

                1. Automate The Grunt Work (The Tedious Tasks That Eat Your Life)

                Every PPC professional has a short list of tasks they love … and a very long list of tasks they tolerate out of necessity. Scripts exist for that second list – the repetitive, time-draining, soul-evaporating work that must get done but doesn’t require human creativity.

                Let’s look at some examples and include some free scripts.

                Budget Pacing

                Google has a very relaxed attitude toward daily budgets. One day, it only spends 60% of your daily budget; the next day, it decides to impress you with a 180% increased spend. Great. But not if your client expects a steady pace and has strict budget requirements.

                A pacing script brings sanity by monitoring both daily and month‑to‑date spend, projecting where your budget will land by the end of the period, and alerting you whenever Google begins to overspend or drift off pace. It highlights pacing issues early and gives you room to adjust budgets proactively – or even automate those adjustments entirely.

                Instead of hoping Google behaves, pacing scripts make sure your budget does.

                Fixing Your Product Feeds

                Any ecommerce manager will tell you: Feeds break constantly, usually at the worst possible moment (think Black Friday, or Christmas, anyone?).

                Instead of leaving you to manually sift through thousands of items, scripts take on the heavy lifting. They can flag missing or invalid GTINs long before they cause disapprovals, detect broken product URLs that quietly tank performance, and surface best-selling items that have suddenly been disapproved.

                Scripts also help uncover missing attributes such as sizes or colors (details that matter for relevance), and can even rewrite product titles dynamically using real search term data to improve impression quality and match user intent more effectively.

                In short, Google Ads scripts help you maintain a clean, high-performing product feed that supports both Shopping and Performance Max success.

                Automated Reporting

                Manual reporting is tolerable for one account. Maybe two. Beyond that? No thanks.

                The PPC Manager who screams “I love creating client reports” … be sure to tell me when you find one.

                Instead of forcing you to manually assemble slides, screenshots, and spreadsheets, scripts take over the entire reporting pipeline. They can automatically export daily, weekly, and monthly performance reports, push the data directly into Google Sheets, and generate clean performance summaries without you lifting a finger. They also build trend dashboards that stay updated in real time, and can even work alongside an LLM to prepare and send a client email that includes the report, along with a short, auto‑generated overview of the key highlights.

                You get reporting consistency without sacrificing your weekends.

                2. Boost Account Performance & Cut Wasted Spend

                Scripts don’t just save time; they actively improve performance. They reveal inefficiencies humans overlook and take action instantly.

                Search Term Analysis & N-Gram Exclusions

                N-gram analysis is one of the most underrated PPC tactics. It breaks queries into word chunks so you can identify patterns of waste.

                Instead of manually combing through endless search term reports, a script can take over the entire process by pulling all queries, breaking them into n‑grams (small one‑, two‑, or three‑word patterns) and analyzing which of those patterns consistently fail to convert. It then identifies common waste phrases and can even auto‑suggest or apply negative keywords based on what it finds.

                If “free,” “DIY,” or “near me” is burning budget across thousands of queries, you’ll know. And you’ll fix it.

                Pausing Non-Converting Products in Shopping & PMax

                No one has time to manually audit thousands of SKUs.

                Scripts can automatically pause products after X spend without conversions, or down-bid poor performers by automatically placing them in a different campaign with higher tROAS and lower max CPC bids.

                This is especially critical for PMax, which happily spends on products you wish it wouldn’t.

                Excluding Bad Display Placements

                Display inventory is unpredictable, and if you’ve ever taken a serious look at your placements report, you already know how messy it can get.

                Click fraud, lead fraud, and brand safety violations are, unfortunately, daily realities in the Display ecosystem.

                This is exactly where scripts earn their keep. Instead of leaving you to manually sift through questionable placements, a script can automatically detect low-quality inventory and remove it from your campaigns. It can identify and exclude MFA sites, pages associated with CSAM or malware risks, and the endless parade of children’s apps that chew through budget without producing meaningful leads. By continuously filtering out these problem areas, scripts can reduce Display waste anywhere from 20% to 60%, depending on your country and account setup.

                Your brand will thank you.

                3. Prevent Costly Mistakes Before They Burn Money

                Scripts excel at catching issues early – before your budgets vanish or Smart Bidding crashes.

                Broken Link Checker

                A broken URL instantly tanks performance, and this is exactly where a link-checker script proves invaluable.

                Instead of relying on manual checks, the script automatically crawls all your final URLs, scanning them for issues such as 404 errors, unexpected redirects, or pages that load so slowly they might as well be broken. When it detects a problem, it alerts you immediately, long before wasted spend or frustrated users pile up.

                You avoid burning budget and annoying potential customers.

                Out-Of-Stock Ad Pausing

                Buying clicks to products that aren’t available is classic ecommerce pain.

                Yes, a well-managed Shopping feed usually prevents this, but for standard Search ads, you’re on your own unless you automate the checks.

                This is where scripts step in. They continuously monitor your product pages to detect when items go out of stock, when certain variants become unavailable, or when products are fully discontinued. Once a problem is spotted, the script automatically pauses the affected ads and then resumes them the moment stock returns, protecting both your budget and user experience.

                Conversion Tracking Monitor

                When conversion tracking breaks, everything breaks – and this is especially true for Google’s Smart Bidding, which becomes completely misaligned the moment your tracking data goes off.

                A monitoring script can catch these issues early by watching for sudden drops in conversions, or unexpected spikes caused by duplicates. The script detects missing enhanced conversions, offline conversions that stop importing, or irregularities in how your tags are firing. It flags these problems the moment they appear, so you can intervene before Smart Bidding optimizes itself into chaos.

                Trust me: When conversion tracking breaks, you want to be the first to know.

                Some Personal Real-Life Examples

                If the examples above haven’t convinced you yet, let me share some personal examples of how scripts saved my neck.

                Account Down Alerts (The Friday 4:55 PM Nightmare Scenario)

                Every PPC manager has lived this.

                A real account alert in one of my clients’ accounts: “Your ads have stopped running – You reached your monthly account spend limit. To get your ads running again, increase your ad spend.”

                This message arrived late on a Friday. No one was looking at the account at that time. Google didn’t send out an email.

                If it weren’t for my script, we wouldn’t have noticed the issue until Monday, and the client would lose out on the weekend revenue.

                Scripts can also act as “real-time account-down watchdogs” by alerting you when your ads suddenly stop serving, when billing fails, and payments can’t be processed, or when monthly or campaign-level spend caps are unexpectedly hit. They also catch situations where Google’s suspension policies kick in or when campaigns shut off without warning for any number of reasons. Instead of discovering these issues hours (or days!) later, scripts make sure you know the moment something breaks.

                Here’s the thing: Google’s notifications aren’t always timely. Script alerts are.

                Change History Monitoring (Protecting Your Account From Humans)

                Some of the most dangerous changes made inside a Google Ads account come from people who shouldn’t have access, from automated third-party tools, or simply from changes that happen unnoticed over a weekend by some auto-applied suggestion.

                A real-life example illustrates this perfectly: One of my clients installed a third-party tracking tool on a Saturday, and the tool quietly modified the account’s tracking templates. Those seemingly small edits broke conversion tracking entirely. If it had gone unnoticed, OCI would have been misaligned and Smart Bidding would’ve optimized against faulty conversion data, performance would certainly go down the drain. This is exactly the kind of situation scripts help prevent.

                My Change History alert script flagged the edit instantly and luckily warned us before real damage was done.

                Monitoring changes in your account is not paranoia. This is survival.

                No Excuse Not To Use Scripts

                There is literally no downside to using scripts, and they’re completely free to run. Scripts are safe because Google’s built-in Preview mode lets you test everything before making actual changes. They’re also incredibly easy to use since most scripts require nothing more than a simple copy-paste to get started. And if you want to customize them, they’re flexible as well; you can modify or extend almost any script with the help of AI in just a few seconds.

                Between Google’s documentation, open‑source script libraries, LLMs, and other tools, creating or customizing scripts has never been easier.

                Final Takeaway: Scripts Are Now Essential PPC Infrastructure

                Running Google Ads without scripts is like flying a plane with half your instruments turned off. Sure, you might land safely – but why take that chance?

                If you care about PPC performance, reliability, or sanity, Google Ads scripts aren’t optional. They’re your watchdog, your analyst, your QA system, and your 24/7 protection against angry clients/bosses.

                Stop wasting budget. Stop working harder than you need to. Start scripting.

                More Resources:


                Featured Image: Accogliente Design/Shutterstock

                Update or delete? Cleaning up old content on your site

                Sometimes, content on your website becomes irrelevant or outdated and you need to decide whether to update it or delete it. It can be tricky to decide what needs to be done, but don’t let this hold you back. Regularly updating outdated content should be a key part of your content maintenance activities. Let’s help you make that decision and discuss when you should update existing content or remove it altogether.

                Update old content that is still valid

                On our blog, we have an article on meta descriptions that needs regular updating to keep it relevant. We just have to ensure it stays up to date with all the changes Google makes to the way it handles meta descriptions. Our post helps people write meta descriptions, even though the advice changes over time. Although the article itself might be what we call cornerstone content, its content must be updated to keep up with the latest standards, constantly.

                You can also create new, valuable content by updating old posts and making them current again: old wine in new bottles, as the saying goes. You can, for example, merge multiple old blog posts about the same subject into one new post or simply replace older parts of your post with updated content.

                A good rule of thumb is to check the amount of traffic you’re getting on a page or post. Are you considering removing a page or unsure about what to do with an outdated one? If that page is still attracting a lot of traffic, it would be a shame to delete it. It would be better to update it to make sure it’s accurate and reflects the latest developments in that field. If the page is not getting a lot of traffic, but the topic is important to you(r company), that can also be a good reason to reevaluate the page and update its content.

                Read more: How to update your content in 10 steps (and make it better) »

                Delete irrelevant posts or pages

                It’s likely that you have old posts or pages on your site that you no longer need. Think along the lines of a blog post about a product you stopped selling a while ago and have no intention of ever selling again. Or an announcement of an event that took place a long time ago. You may also have old pages with little or no content, known as thin content pages. This outdated content no longer adds value, now or in the foreseeable future. In that case, you need to either make it clear that this content is no longer relevant or assign the URL a new purpose.

                When we talk about deleting old content, I don’t mean simply pressing “delete” and forgetting about it. If you do that, the content may still appear in Google search results for weeks after deletion. The URL might actually have some link value as well, which would be a shame to waste. So, what should you do? Here are two options:

                “301 Redirect” the old post to a related one

                When a URL still holds value because, say, you have a number of quality links pointing to that page, you want to leverage that value by redirecting the URL to a related one. With a 301 redirect, you’ll inform search engines and visitors that a better or newer version of this content can be found elsewhere on your site. The 301 redirect automatically sends people and Google to this page.

                Say you have an old post on a specific product. You need to delete it, so the logical next step would be to redirect that post to a newer post about this product. If you don’t have that post, choose a post about the closest product possible. One that can still help out the user in a way that the old product would. Redirecting to a relevant category might be an option in some edge cases, but this should not be standard practice. Furthermore, redirecting to the homepage should be avoided — this is an SEO anti-pattern.

                There are a few ways to create a 301 redirect in WordPress, but using the redirect manager in Yoast SEO Premium makes it incredibly easy.

                Tell search engines the content is intentionally gone

                If there isn’t a relevant page on your site to redirect to, it’s wise to tell Google to forget about your old post entirely by serving a “410 Deleted” status. This status code will tell Google and visitors that the content didn’t just disappear; you’ve deleted it with a reason.

                When Google can’t find a post, the server typically returns a “404 Not Found” status to the search engine’s bot. You’ll also find a 404 crawl error in your Google Search Console for that page. Eventually, Google will work it out, and the URL will gradually vanish from the search result pages. But this takes time.

                The 410 is more powerful in the sense that it informs Google that the page is permanently deleted and will never be available again. You deleted it on purpose. Google will act on that faster than with a 404. Read up about the server status codes if this is all gibberish to you.

                Keep reading: How to properly delete a page from your site »

                Do you have old content to deal with?

                Cleaning up old content should be part of your content maintenance routine. If you don’t review your old posts regularly, you’re bound to encounter issues sooner or later. You might show incorrect information to visitors or hurt your own rankings by having too many pages about the same topic, increasing the chances of keyword cannibalization. So prune your content regularly and decide what to do: update, merge or delete.

                Clean up orphaned content with Yoast SEO Premium

                A great place to start is with your orphaned content, which is content that has zero internal links to it. You might be surprised, but most of us have orphaned content on our website. Which is a shame, because both your audience and Google won’t be able to find this content. Meaning that you might be missing out on a great place in the search results and lots of traffic.

                To help you clean up your old content, we’ve created an SEO workout that identifies those pages and guides you through four simple steps to fix them. These steps enable you to determine whether you want to update or delete a page. And when you do decide to update it, it also suggests pages or posts from which you can link to this updated content.

                The first step in the orphaned content workout in Yoast SEO Premium

                You will need Yoast SEO Premium to use this workout. You might also want to try our other internal linking SEO workout to help you rank higher with your best content, also available in the Premium plugin:

                Unlock our SEO workouts with Yoast SEO Premium

                Get Yoast SEO Premium and enjoy access to all our best SEO tools, training and SEO workouts!

                This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity”

                At some point next month, a handful of volunteers will be injected with two experimental gene therapies as part of an unusual clinical trial. The drugs are potential longevity therapies, says Ivan Morgunov, the CEO of Unlimited Bio, the company behind the trial. His long-term goal: to achieve radical human life extension.

                The 12 to 15 volunteers—who will be covering their own travel and treatment costs—will receive a series of injections in the muscles of their arms and legs. One of the therapies is designed to increase the blood supply to those muscles. The other is designed to support muscle growth. The company hopes to see improvements in strength, endurance, and recovery. It also plans to eventually trial similar therapies in the scalp (for baldness) and penis (for erectile dysfunction).

                But some experts are concerned that the trial involves giving multiple gene therapies to small numbers of healthy people. It will be impossible to draw firm conclusions from such a small study, and the trial certainly won’t reveal anything about longevity, says Holly Fernandez Lynch, a lawyer and medical ethicist at the University of Pennsylvania in Philadelphia.

                Unlimited Bio’s muscle growth therapy is already accessible at clinics in Honduras and Mexico, says Morgunov—and the company is already getting some publicity. Khloe Kardashian tagged Unlimited Bio in a Facebook post about stem-cell treatments she and her sister Kim had received at the Eterna clinic in Mexico in August. And earlier this week, the biohacking influencer Dave Asprey posted an Instagram Reel of himself receiving one of the treatments in Mexico; it was shared with 1.3 million Instagram followers. In the video, Eterna’s CEO, Adeel Khan, says that the therapy can “help with vascular health systemically.” “I’m just upgrading my system for a little while to reduce my age and reduce my vascular risk,” Asprey said.

                Genes for life

                Gene therapies typically work by introducing new genetic code into the body’s cells. This code is then able to make proteins. Existing approved gene therapies have typically been developed for severe diseases in which the target proteins are either missing or mutated.

                But several groups are exploring gene therapies for healthy people. One of these companies is Minicircle, which developed a gene therapy to increase production of follistatin, a protein found throughout the body that has many roles and is involved in muscle growth. The company says this treatment will increase muscle mass—and help people live longer. Minicircle is based in Próspera, a special economic zone in Honduras with its own bespoke regulatory system. Anyone can visit the local clinic and receive that therapy, for a reported price of $25,000. And many have, including the wealthy longevity influencer Bryan Johnson, who promoted the therapy in a Netflix documentary.

                Unlimited Bio’s Morgunov, a Russian-Israeli computer scientist, was inspired by Minicircle’s story. He is also interested in longevity. Specifically, he’s committed to radical life extension and has said that he could be part of “the last generation throughout human history to die from old age.” He believes the biggest “bottleneck” slowing progress toward anti-aging or lifespan-extending therapies is drug regulation. So he, too, incorporated his own biotech company in Próspera.

                “A company like ours couldn’t exist outside of Próspera,” says Unlimited Bio’s chief operating officer, Vladimir Leshko.

                There, Morgunov and his colleagues are exploring two gene therapies. One of these is another follistatin therapy, which the team hopes will increase muscle mass. The other codes for a protein called vascular endothelial growth factor, or VEGF. This compound is known to encourage the growth of blood vessels. Morgunov and his colleagues hope the result will be increased muscle growth, enhanced muscle repair, and longer life. Neither treatment is designed to alter a recipient’s DNA, and therefore it won’t be inherited by future generations.

                The combination of the two therapies could benefit healthy people and potentially help them live longer, says Leshko, a former electrical engineer and professional poker player who retrained in biomedical engineering. “We would say that it’s a preventive-slash-enhancing indication,” he says. “Potentially participants can experience faster recovery from exercise, more strength, and more endurance.”

                Of the 12 to 15 volunteers who participate in the trial, half will receive only the VEGF therapy. The other half will receive both the VEGF and the follistatin therapies. The treatments will involve a series of injections throughout large muscles in the arms and legs, says Morgunov.

                He is confident that the VEGF therapy is safe. It was approved in Russia over a decade ago to treat lower-limb ischemia—a condition that can cause pain, numbness, and painful ulcers in the legs and feet. Morgunov reckons that around 10,000 people in Russia have already had the drug, although he says he hasn’t “done deep fact-checking on that.”

                Other researchers aren’t convinced.

                Limited bio

                VEGF is a powerful compound, says Seppo Ylä-Herttuala, a professor of molecular medicine at the University of Eastern Finland who has been studying VEGF and potential VEGF therapies for decades. He doesn’t know how many people have had VEGF gene therapy in Russia. But he does know that the safety of the therapy will depend on how much is administered and where. Previous attempts to inject the therapy into the heart, for example, have resulted in edema, a sometimes fatal buildup of fluid. Even if the therapy is injected elsewhere, VEGF can travel around the body, he says. If it gets to the eye, for example, it could cause blindness. Leshko counters that the VEGF should remain where it is injected, and any other circulation in the body, if it occurs, should be short-lived. 

                And while the therapy has been approved in Russia, there’s a reason it hasn’t been approved elsewhere, says Ylä-Herttuala: The clinical trials were not as rigorous as they could have been. While “it probably works in some patients,” he says, the evidence to support the use of this therapy is weak. At any rate, he adds, VEGF will only support the growth of blood vessels—it won’t tackle aging.  “VEGF is not a longevity drug,” he says.

                Leshko points to a 2021 study in mice, which suggested that a lack of VEGF activity might drive aging in the rodents. “We’re convinced it qualifies as a potential longevity drug,” he says.

                There is even less data about follistatin. Minicircle, the company selling another follistatin gene therapy, has not published any rigorous clinical trial data. So far, much of the evidence for follistatin’s effects comes from research in rodents, says Ylä-Herttuala.

                Clinical trials like this one should gather more information, both about the therapies and about the methods used to get those therapies into the body. Unlimited Bio’s VEGF therapy will be delivered via a circular piece of genetic code called a plasmid. Its follistatin therapy, on the other hand, will be delivered via an adeno-associated virus (AAV). Plasmid therapies are easier to make, and they have a shorter lifespan in the body—only a matter of days. They are generally considered to be safer than AAV therapies. AAV therapies, on the other hand, tend to stick around for months, says Ylä-Herttuala. And they can trigger potentially dangerous immune reactions.

                It’s debatable whether healthy people should be exposed to these risks, says Fernandez Lynch. The technology “still has serious questions about its safety and effectiveness,” even for people with life-threatening diseases, she says. “If you are a healthy person, the risk of harm is more substantial because it’ll be more impactful on your life.”

                But Leshko is adamant. “Over 120,000 humans die DAILY from age-related causes,” he wrote in an email. “Building ‘ethical’ barriers around ‘healthy’ human (in fact, aging human) trials is unethical.” Morgunov did not respond to a request for comment.

                Some people want to take those risks anyway. In his video, the biohacker influencer Asprey—who has publicly stated that he’s “going to live to 180”—described VEGF as a “longevity compound,” and Eterna’s CEO Khan, who delivered the treatment, described it as “the ultimate upgrade.” Neither Asprey nor Khan clinic responded to requests for comment. 

                Michael Gusmano, a professor of health policy at Lehigh University in Bethlehem, Pennsylvania, worries that this messaging might give trial participants unrealistic expectations about how they might benefit. There is “huge potential for therapeutic misconception when you have some kind of celebrity online influencer touting something about which there is relatively sparse scientific evidence,” he says. In reality, he adds, “the only thing you can guarantee is that [the volunteers] will be contributing to our knowledge of how this intervention works.”

                “I would certainly not recommend that anyone I know enter into such a trial,” says Gusmano.

                A penis project

                The muscle study is only the first step. The Unlimited Bio team hopes to trial the VEGF therapy for baldness and erectile dysfunction, too. Leshko points to research in mice that links high VEGF levels to larger, denser hair follicles. He hopes to test a series of VEGF therapy injections into the scalps of volunteers. Morgunov, who is largely bald, has already started to self-experiment with the approach.

                An erectile dysfunction trial may follow. “That one we think has great potential because injecting gene therapy into the penis sounds exciting,” says Leshko. A protocol for that trial has not yet been finalized, but he imagines it would involve “five to 10” injections.

                Ylä-Herttuala isn’t optimistic about either approach. Hair growth is largely hormonal, he says. And injecting anything into a penis risks damaging it (although Leshko points out that a similar approach was taken by another company almost 20 years ago). Injecting a VEGF gene therapy into the penis would also risk edema there, Ylä-Herttuala adds.

                And he points out that we already have some treatments for hair loss and erectile dysfunction. While they aren’t perfect, their existence does raise the bar for any potential future therapies—not only do they have to be safe and effective, but they must be safer or more effective than existing ones.

                That doesn’t mean the trials will flop. No small trial can be definitive, but it could still provide some insight into how these drugs are working. It is possible that the therapies will increase muscle mass, at least, and that this could be beneficial to the healthy recipients, says Ylä-Herttuala. 

                Before our call, he had taken a look at Unlimited Bio’s website, which carries the tagline “The Most Advanced Rejuvenation Solution.” “They promise a lot,” he said. “I hope it’s true.”